Antistaphylococcal vaccines and immunloglobulins - Current status and future prospects

被引：12
作者：
Deresinski, Stan
机构：
[1] Stanford Univ, Stanford, CA 94305 USA
[2] Santa Clara Valley Med Ctr, San Jose, CA 95128 USA
来源：
DRUGS | 2006年 / 66卷 / 14期
关键词：
D O I：
10.2165/00003495-200666140-00002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Staphylococci are among the most frequently encountered pathogens in both inpatient and the outpatient setting. Management of infections caused by these is complicated by the increasingly common resistance of staphylococal pathogens to commonly used antibacterials. As a consequence, novel to prevention and treatment are urgently required. Such approaches the development of vaccines and immunoglobulin preparations targeted at virulence factors expressed in vivo by staphylococci. This article reviews the progress made to date in this field and suggests approaches to further progress.
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收藏
页码：1797 / 1806
页数：10
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共 77 条
[1]   Recurrent nonmenstrual toxic shock syndrome: Clinical manifestations, diagnosis, and treatment [J].
Andrews, MM ;
Parent, EM ;
Barry, M ;
Parsonnet, J .
CLINICAL INFECTIOUS DISEASES, 2001, 32 (10) :1470-1479
[2]   The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus [J].
Appelbaum, PC .
CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 :16-23
[3]   A blinded, randomized, multicenter study of an intravenous Staphylococcus aureus immune globulin [J].
Benjamin, D. K., Jr. ;
Schelonka, R. ;
White, R. ;
Holley, H. P., Jr. ;
Bifano, E. ;
Cummings, J. ;
Adcock, K. ;
Kaufman, D. ;
Puppala, B. ;
Riedel, P. ;
Hall, B. ;
White, J. ;
Cotten, C. M. .
JOURNAL OF PERINATOLOGY, 2006, 26 (05) :290-295
[4]  
*BIOS INC, PROD CAND BSYX A110
[5]   Multicenter study to assess safety and efficacy of INH-A21 a donor-selected human staphylococcal immunoglobulin, for prevention of nosocomial infections in very low birth weight infants [J].
Bloom, B ;
Schelonka, R ;
Kueser, T ;
Walker, W ;
Jung, E ;
Kaufman, D ;
Kesler, K ;
Roberson, D ;
Patti, J ;
Hetherington, S .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2005, 24 (10) :858-866
[6]   Identification of an immunodominant ABC transporter in methicillin-resistant Staphylococcus aureus infections [J].
Burnie, JP ;
Matthews, RC ;
Carter, T ;
Beaulieu, E ;
Donohoe, M ;
Chapman, C ;
Williamson, P ;
Hodgetts, SJ .
INFECTION AND IMMUNITY, 2000, 68 (06) :3200-3209
[7]   Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human staphylococcal immune globulin, in low-birth-weight infants [J].
Capparelli, EV ;
Bloom, BT ;
Kueser, TJ ;
Oelberg, DG ;
Bifano, EM ;
White, RD ;
Schelonka, RL ;
Pearlman, SA ;
Patti, J ;
Hetherington, SV .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (10) :4121-4127
[8]   National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004 [J].
Cardo, D ;
Horan, T ;
Andrus, M ;
Dembinski, M ;
Edwards, J ;
Peavy, G ;
Tolson, J ;
Wagner, D .
AMERICAN JOURNAL OF INFECTION CONTROL, 2004, 32 (08) :470-485
[9]   Immunization with glutathione S-transferase and mutant toxic shock syndrome toxin 1 fusion protein protects against Staphylococcus aureus infection [J].
Cui, JC ;
Hu, DL ;
Lin, YC ;
Qian, AD ;
Nakane, A .
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2005, 45 (01) :45-51
[10]   Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens:: Implications for therapy of toxic shock syndrome [J].
Darenberg, J ;
Söderquist, B ;
Normark, BH ;
Norrby-Teglund, A .
CLINICAL INFECTIOUS DISEASES, 2004, 38 (06) :836-842
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