Influences of Flavonoids on Erythrocyte Membrane and Metabolic Implication Through Anionic Exchange Modulation

被引：51

作者：

Barreca, Davide ^{[1
]}

Lagana, Giuseppina ^{[1
]}

Tellone, Ester ^{[1
]}

Ficarra, Silvana ^{[1
]}

Leuzzi, Ugo ^{[1
]}

Galtieri, Antonio ^{[1
]}

Bellocco, Ersilia ^{[1
]}

机构：

[1] Univ Messina, Dept Organ & Biol Chem, Messina, Italy

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2009年 / 230卷 / 03期

关键词：

Membrane integrity; Band; 3; protein; Antioxidant; Erythrocyte; Caspase-3; Hydrogen peroxide; Metabolic modulation; BAND-3 PROTEIN FUNCTION; RED-BLOOD-CELLS; OXYGENATION-DEOXYGENATION; INHIBITION; HEMOGLOBIN; COCOA; ACTIVATION; APOPTOSIS; CASPASE-3; TRANSPORT;

D O I：

10.1007/s00232-009-9197-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antioxidative activity of some natural flavonoids was analyzed against the stable free radical 2,2-diphenyl-1-picryhydrazyl. The results indicate that the scavenging power of the tested flavonols is higher than that of the synthetic antioxidants butylated hydroxyanisole and butylated hydroxytoluene; instead, the flavanones show little activity, as indicated by efficient concentration (EC50) values. Flavonoid autoxidation and interaction with Fe2+ and hydrogen peroxide were tested using erythrocyte membranes as a model. The results show that some compounds, like hesperetin, evidence a pro-oxidant activity higher than the ascorbic acid/iron reference system. The compounds with strong oxidative capability do not only influence cellular redox balance but also activate caspase-3, producing lactate dehydrogenase release and enhancing anionic exchange at the level of band 3 protein.

引用

页码：163 / 171

页数：9

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