GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?

被引:6
作者
Beuers, Ulrich [1 ]
Goeke, Burkhard [2 ]
机构
[1] Univ Amsterdam, Dept Gastroenterol & Hepatol, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands
[2] Univ Munich, Dept Med 2, Klinikum Grosshadern, D-80539 Munich, Germany
关键词
TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; BILE-DUCTS; CHOLESTASIS; LIVER; EXENDIN-4; MECHANISM; SURVIVAL; RECEPTOR; AGONIST;
D O I
10.1136/gut.2008.165688
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:902 / 903
页数:4
相关论文
共 14 条
[1]   Proliferating cholangiocytes: A neuroendocrine compartment in the diseased liver [J].
Alvaro, Domenico ;
Mancino, Maria Grazia ;
Glaser, Shannon ;
Gaudio, Eugenio ;
Marzioni, Marco ;
Francis, Heather ;
Alpini, Gianfranco .
GASTROENTEROLOGY, 2007, 132 (01) :415-431
[2]   Biology of incretins: GLP-1 and GIP [J].
Baggio, Laurie L. ;
Drucker, Daniel J. .
GASTROENTEROLOGY, 2007, 132 (06) :2131-2157
[3]  
Bayliss WM, 1902, J PHYSIOL-LONDON, V28, P325
[4]   Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis [J].
Beuers, Ulrich .
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2006, 3 (06) :318-328
[5]   Crosstalk of Liver, Bile Ducts and the Gut [J].
Beuers, Ulrich .
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2009, 36 (01) :1-3
[6]  
GOKE R, 1993, J BIOL CHEM, V268, P19650
[7]   The cholangiopathies: Disorders of biliary epithelia [J].
Lazaridis, KN ;
Strazzabosco, M ;
Larusso, NF .
GASTROENTEROLOGY, 2004, 127 (05) :1565-1577
[8]   Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts [J].
Marzioni, M ;
Francis, H ;
Benedetti, A ;
Ueno, Y ;
Fava, G ;
Venter, J ;
Reichenbach, R ;
Mancino, MG ;
Summers, R ;
Alpini, G ;
Glaser, S .
AMERICAN JOURNAL OF PATHOLOGY, 2006, 168 (02) :398-409
[9]   Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis [J].
Marzioni, M. ;
Alpini, G. ;
Saccomanno, S. ;
Candelaresi, C. ;
Venter, J. ;
Rychlicki, C. ;
Fava, G. ;
Francis, H. ;
Trozzi, L. ;
Benedetti, A. .
GUT, 2009, 58 (07) :990-997
[10]   Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis [J].
Marzioni, Marco ;
Alpini, Gianfranco ;
Saccomanno, Stefania ;
Candelaresi, Cinzia ;
Venter, Juliet ;
Rychlicki, Chiara ;
Fava, Giammarco ;
Francis, Heather ;
Trozzi, Luciano ;
Glaser, Shannon ;
Benedetti, Antonio .
GASTROENTEROLOGY, 2007, 133 (01) :244-255