Determination of the stereochemistry of (-)-koninginin A by an X-ray analysis of its synthetic sample

被引：4

作者：

Mori, K

Bando, M

Abe, K

机构：

[1] Fuji Flavor Co Ltd, Insect Pheromone & Traps Div, Hamura City, Tokyo 2058503, Japan

[2] Otsuka Pharmaceut Co Ltd, Organ Chem Res Inst, Tokushima 7710192, Japan

[3] Otsuka Pharmaceut Co Ltd, Tokushima Factory 2nd, Tokushima Factory 2, Tokushima 7710192, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 08期

关键词：

antibiotics; koninginin A; Trichoderma koningii; Trichoderma harzianum; X-ray analysis;

D O I：

10.1271/bbb.66.1779

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The absolute configuration of (-)-koninginin A (10-hexyl-11,12-dioxatricyclo[7.2.1.0<1,6>]dodecane-2,5-diol (1)), the antibiotic metabolite of Trichoderma koningii and T. harzianum, was determined as 1S, 2R, 5S, 6S, 9S, 10S by an X-ray crystallographic analysis of its synthetic sample coupled with the established stereochemical outcome of Sharpless asymmetric dihydroxylation used as the key reaction to prepare intermediate 4.

引用

页码：1779 / 1781

页数：3

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