The genetics of systemic lupus erythematosus:: understanding how SNPs confer disease susceptibility

被引：14

作者：

Alarcon-Riquelme, Marta E. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 2006年 / 28卷 / 02期

关键词：

D O I：

10.1007/s00281-006-0033-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of genes for autoimmune diseases is just the first step towards our understanding of disease pathogenesis. In investigating how mutations, deletions or other types of polymorphic defects occur, it is important to determine the pathways and the mechanisms through which susceptibility leads to disease. In this review I touch on three examples of studies that have attempted to understand the mechanisms of genetic susceptibility in three genes identified recently for systemic lupus erythematosus: PDCD1, PTPN22 and IRF5. We are just beginning to comprehend and much needs to be done.

引用

页码：109 / 117

页数：9

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