Hydrogen peroxide upregulates TNF-related apoptosis-inducing ligand (TRAIL) expression in human astroglial cells, and augments apoptosis of T cells

被引：10
|
作者：
Kwon, Daeho
Choi, In-Hong
机构：
[1] Yonsei Univ, Coll Med, Dept Microbiol, Inst Immunol & Immunol Dis, Seoul 120752, South Korea
[2] Ajou Univ, Sch Med, Dept Microbiol, Seoul, South Korea
来源：
YONSEI MEDICAL JOURNAL | 2006年 / 47卷 / 04期
关键词：
astroglial cells; hydrogen peroxide; TRAIL; cyclosporin A; apoptosis; oxidative stress; neuroimmunology;
D O I：
10.3349/ymj.2006.47.4.551
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The brain is particularly vulnerable to oxygen free radicals, and these radicals have been implicated in the pathology of several neurological disorders. In this study, the modulation of TNF-related apoptosis-inducing ligand (TRAIL) expression by oxidative stress was shown in LN215 cells, an astroglioma cell line. Hydrogen peroxide (H2O2) treatment increased TRAIL expression in LN215 cells and H2O2-induced TRAIL augmented apoptosis in Peer cells, a cell line sensitive to TRAIL-mediated cell death. Our findings suggest that the upregulation of TRAIL in astroglial cells may abrogate immune cell effector functions.
引用
收藏
页码：551 / 557
页数：7
相关论文
共 50 条
  • [31] TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling
    Guerrache, Abderrahmane
    Micheau, Olivier
    CELLS, 2024, 13 (06)
  • [32] TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation from monocyte/macrophage lineage precursor cells
    Yen, Men-Luh
    Tsai, Hwei-Fang
    Wu, Yi-Ying
    Hwa, Hsiao-Lin
    Lee, Be-Hang
    Hsu, Ping-Ning
    MOLECULAR IMMUNOLOGY, 2008, 45 (08) : 2205 - 2213
  • [33] Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis
    Kutlu, Omer
    Akkaya, Erdem
    Koksal, Ismail Turker
    Bassorgun, Ibrahim Cumhur
    Ciftcioglu, Mehmet Akif
    Sanlioglu, Salih
    Kukul, Erdal
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2010, 42 (02) : 393 - 399
  • [34] Stability and bioactivity of nanocomplex of TNF-related apoptosis-inducing ligand
    Na, Seong Ju
    Chae, Su Young
    Lee, Seulki
    Park, Kyeongsoon
    Kim, Kwangmeyung
    Park, Jae Hyung
    Kwon, Ick Chan
    Jeong, Seo Young
    Lee, Kang Choon
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 363 (1-2) : 149 - 154
  • [35] TNF-related apoptosis-inducing ligand suppresses PRDX4 expression
    Wang, Hua-Qin
    Du, Zhen-Xian
    Liu, Bao-Qin
    Gao, Yan-Yan
    Meng, Xin
    Guan, Yifu
    Zhang, Hai-Yan
    FEBS LETTERS, 2009, 583 (09) : 1511 - 1515
  • [36] Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-κB activation
    Kye Young Lee
    Jae Seuk Park
    Young Koo Jee
    Glenn D Rosen
    Experimental & Molecular Medicine, 2002, 34 : 462 - 468
  • [37] Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-κB activation
    Lee, KY
    Park, JS
    Jee, YK
    Rosen, GD
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2002, 34 (06) : 462 - 468
  • [38] Expression of human TNF-related apoptosis-inducing ligand extracellular region in E. coli
    唐蓓
    Journal of Chongqing University, 2002, (02) : 54 - 56
  • [39] Evidence for a proangiogenic activity of TNF-related apoptosis-inducing ligand
    Secchiero, P
    Gonelli, A
    Carnevale, E
    Corallini, F
    Rizzardi, C
    Zacchigna, S
    Melato, M
    Zauli, G
    NEOPLASIA, 2004, 6 (04): : 364 - 373
  • [40] Cell to cell contact required for bystander effect of the TNF-related apoptosis-inducing ligand (TRAIL) gene
    Huang, XF
    Lin, TY
    Gu, J
    Zhang, LD
    Roth, JA
    Liu, JS
    Fang, BL
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2003, 22 (06) : 1241 - 1245
12345