Novel Clonal der(9)t(5;9)(q31;q34) Cytogenetic Translocation in a Giant Cell Tumor of Bone

被引：0

作者：

Santosh, Neetha ^{[1
]}

Heerema, Nyla A. ^{[2
]}

Mayerson, Joel L. ^{[3
]}

Iwenofu, Obiajulu H. ^{[2
]}

机构：

[1] Ohio State Univ, Coll Dent, Div Oral & Maxillofacial Pathol & Radiol, Columbus, OH 43210 USA

[2] Ohio State Univ, Wexner Med Ctr, Dept Pathol & Lab Med, Columbus, OH 43210 USA

[3] Ohio State Univ, Wexner Med Ctr, Dept Orthopaed, Columbus, OH 43210 USA

来源：

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | 2015年 / 23卷 / 10期

关键词：

giant cell tumor of bone; chromosomal abnormalities; clonal translocation; TELOMERIC ASSOCIATIONS; CHROMOSOMAL-ABNORMALITIES; ABERRATIONS; LEUKEMIA;

D O I：

10.1097/PAI.0000000000000281

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Giant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm of long bones with higher chances of local recurrence. Many cytogenetic studies have reported clonal telomeric associations with GCTB. Here, we report for the first time a novel clonal translocation, der(9)t(5;9)(q31;q34), in a 25-year-old male patient with GCTB in the left distal femur. The biological significance of this translocation remains to be determined.

引用

页码：e17 / e21

页数：5

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