In vitro inhibition effects of some new sulfonamide inhibitors on human carbonic anhydrase I and II

被引：6
|
作者：
Çakir, Ü
Ugras, HI
Özensoy, Ö
Sínan, S
Arslan, O [1 ]
机构：
[1] Balikesir Univ Sci & Art Fac, Dept Chem, TR-10100 Balikesir, Turkey
[2] Balikesir Univ Sci & Art Fac, Dept Biol, TR-10100 Balikesir, Turkey
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 03期
关键词：
inhibition; sulfonamides; carbonic anhydrase isozymes;
D O I：
10.1080/14756360410001689586
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new series of aromatic and heterocyclic sulfonamides, including six new derivatives, 2-(3-cyclohexene-1-carbamido)-1,3,4-thiadiazole-5-sulfonamide (CCTS), 4-(3-cyclohexene-1-carbamido) methyl-benzenesulfonamide (CCBS), 2-(9-octadecenoylamido)-1,3,4-thiadiazole-5-sulfonamide (ODTS), 2-(4,7,10-trioxa-tetradecanoylamido)1,3,4-thiadiazole-5-sulfonamide (TDTS), 2-(coumarine-3-carbamido)-1,3,4-thiadiazole-5-sulfonamide (COTS) and 2-(8-methoxycoumarine-3-carbamido)-1,3,4-thiadiazole-5-sulfonamide (MCTS), has been investigated. These sulfonamides were assayed for inhibition of human carbonic anhydrase I (hCA-I) and human carbonic anhydrase II (hCA-II) which were purified by affinity chromatography.
引用
收藏
页码：257 / 261
页数：5
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