Focal adhesion protein expression in human diffuse large B-cell lymphoma

被引：14

作者：

Bosch, Rosa ^{[1
]}

Dieguez-Gonzalez, Rebeca ^{[1
]}

Jose Moreno, Maria ^{[1
]}

Gallardo, Alberto ^{[2
]}

Novelli, Silvana ^{[3
,4
]}

Espinosa, Inigo ^{[4
,5
]}

Virtudes Cespedes, Maria ^{[1
,6
]}

Angel Pavon, Miguel ^{[1
]}

Briones, Javier ^{[3
,4
]}

Granena, Albert ^{[7
]}

Sierra, Jorge ^{[3
,4
]}

Mangues, Ramon ^{[1
,6
]}

Casanova, Isolda ^{[1
,6
]}

机构：

[1] Inst Invest Biomed St Pau, GOA, Barcelona 08028, Spain

[2] Clin Girona, Dept Pathol, Girona, Spain

[3] Hosp Santa Creu & Sant Pau, Dept Haematol, Barcelona, Spain

[4] Red Temat Invest Cooperat Canc RETICC, Barcelona, Spain

[5] Hosp Sant Creu & St Pau, Dept Pathol, Barcelona, Spain

[6] CIBER BBN, Barcelona, Spain

[7] Hosp Univ Bellvitge, Dept Haematol, Barcelona, Spain

来源：

HISTOPATHOLOGY | 2014年 / 65卷 / 01期

关键词：

diffuse; focal adhesions; large B-cell lymphoma; prognosis; TYROSINE KINASE 2; ANTIGEN RECEPTOR; REDUCED EXPRESSION; SIGNALING PATHWAY; DOCKING PROTEIN; BREAST-CANCER; GROWTH-FACTOR; PYK2; PHOSPHORYLATION; P130(CAS);

D O I：

10.1111/his.12381

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aims: Focal adhesions have been associated with poor prognosis in multiple cancer types, but their prognostic value in diffuse large B-cell lymphoma (DLBCL) has not been evaluated. The aim of this study was to investigate the expression patterns and the prognostic value of the focal adhesion proteins FAK, Pyk2, p130Cas and HEF1 in DLBCL. Methods and results: Focal adhesion protein expression was examined using immunohistochemistry in normal lymphoid tissues and in 60 DLBCL patient samples. Kaplan-Meier survival and Cox regression analysis were performed to evaluate the correlation of focal adhesion protein expression with patient prognosis. FAK, Pyk2, p130Cas and HEF1 expression was mostly found in the germinal centres of normal human lymphoid tissues. When assessed in DLBCL samples, FAK, Pyk2, p130Cas and HEF1 were highly expressed in 45%, 34%, 42% and 45% of the samples, respectively. Multivariate Cox analysis revealed that decreased FAK expression was a significant independent predictor of poorer disease outcome. Conclusions: FAK expression is an independent prognostic factor in DLBCL. Our results suggest that the addition of FAK immunostaining to the current immunohistochemical algorithms may facilitate risk stratification of DLBCL patients.

引用

页码：119 / 131

页数：13

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