Interaction of graphene oxide with human serum albumin and its mechanism

被引：58

作者：

Ding, Zhijia ^{[1
,2
,3
]}

Ma, Hongwei ^{[1
]}

Chen, Yanyan ^{[1
]}

机构：

[1] Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Div Nanobiomed, Key Lab Nanobio Interface Res, Suzhou 215123, Peoples R China

[2] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 98期

基金：

中国国家自然科学基金;

关键词：

PHOTOTHERMAL THERAPY; GOLD NANOPARTICLES; CIRCULAR-DICHROISM; DRUG-DELIVERY; PROTEIN; CONFORMATION; BINDING; WATER; CYTOTOXICITY; BIOSENSORS;

D O I：

10.1039/c4ra09613d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Human serum albumin (HSA) is chosen to investigate the interaction of graphene oxide-based nanosheets (GONS) with plasma proteins in terms of binding affinity, action mechanism, conformational change and function loss. We show that GONS inhibit HSA function via two routes: blocking protein active sites, or destroying protein structure.

引用

收藏

页码：55290 / 55295

页数：6

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