Anti-SARS-Cov-2 IgA Response in Tears of COVID-19 Patients

被引：20

作者：

Caselli, Elisabetta ^{[1
,2
]}

Soffritti, Irene ^{[1
,2
]}

Lamberti, Giuseppe ^{[3
]}

D'Accolti, Maria ^{[1
,2
]}

Franco, Filippo ^{[3
]}

Demaria, Davide ^{[3
]}

Contoli, Marco ^{[4
]}

Passaro, Angela ^{[4
]}

Contini, Carlo ^{[5
]}

Perri, Paolo ^{[4
]}

机构：

[1] Univ Ferrara, Dept Chem & Pharmaceut Sci, I-44121 Ferrara, Italy

[2] Univ Ferrara, LTTA, Microbiol Sect, I-44121 Ferrara, Italy

[3] Univ Ferrara, Dept Biomed & Surg Specialized Sci, Ophthalmol Unit, I-44121 Ferrara, Italy

[4] Univ Ferrara, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy

[5] Univ Ferrara, Dept Med Sci, Infect Dis Unit, I-44121 Ferrara, Italy

来源：

BIOLOGY-BASEL | 2020年 / 9卷 / 11期

关键词：

SAR-CoV-2; IgA; eye; COVID-19; SARS-COV-2; INFECTION; SURFACE;

D O I：

10.3390/biology9110374

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Simple Summary SARS-CoV-2 can enter the body via the eye but the local antiviral response is still poorly known, we thus analyzed the presence of mucosal antibodies in the tears of COVID-19 patients. The results show that 35.7% of COVID-19 subjects have specific antiviral secretory antibodies in the eye. Their detection may be extremely helpful in clarifying, at this level, virus pathology and epidemiology. The pandemic virus SARS-CoV-2 has been reported to be able to enter the body via the eye conjunctiva, but the presence of antiviral response in the eye remains poorly known. Our study was thus aimed to analyze the presence of secretory mucosal anti-SARS-CoV-2 type A immunoglobulins (IgA) in the conjunctival fluid of COVID-19 patients. The tears of 28 COVID-19 patients and 20 uninfected controls were collected by the Schirmer test and analyzed by a specific ELISA assay detecting anti-spike (S1) virus protein IgA. The results showed that 35.7% of COVID-19 subjects have specific antiviral IgA at the ocular level, persisting till 48 days post disease onset. Most of the IgA positive subjects presented mild symptoms. The collected data indicate a prolonged persistence of anti-SARS-CoV-2 IgA at the eye level and suggest that IgA detection may be extremely helpful in clarifying virus pathology and epidemiology.

引用

页码：1 / 11

页数：11

共 42 条

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