Dexamethasone dosing for prevention of acute chemotherapy-induced vomiting in pediatric patients: A systematic review

被引：10

作者：

Patel, Priya ^{[1
]}

Olteanu, Ana ^{[2
]}

Cabral, Sandra ^{[1
]}

Santesso, Nancy ^{[3
]}

Robinson, Paula D. ^{[1
]}

Dupuis, L. Lee ^{[2
,4
,5
]}

机构：

[1] Pediat Oncol Grp Ontario, Toronto, ON, Canada

[2] Hosp Sick Children, Child Hlth Evaluat Sci Res Inst, Toronto, ON, Canada

[3] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

[4] Univ Toronto, Hosp Sick Children, Dept Pharm, Toronto, ON, Canada

[5] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2020年 / 67卷 / 12期

关键词：

chemotherapy-induced nausea and vomiting; dexamethasone; pediatric oncology; supportive care; INDUCED NAUSEA; DOUBLE-BLIND; PLUS DEXAMETHASONE; EMETOGENIC CHEMOTHERAPY; ADOLESCENT PATIENTS; CHILDREN; CANCER; PLACEBO; EMESIS; ONDANSETRON;

D O I：

10.1002/pbc.28716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A systematic review was undertaken to describe dexamethasone doses studied for chemotherapy-induced vomiting (CIV) prophylaxis in pediatric patients and their effects on achieving complete acute CIV control. No dose-finding studies were identified. However, 16 studies assessing pediatric patients who received dexamethasone were included and classified according to the emetogenicity of chemotherapy administered. Eight different total daily dexamethasone doses were administered to patients on day 1 of highly emetogenic chemotherapy: three in conjunction with aprepitant/fosaprepitant plus a 5HT(3)antagonist and five in conjunction with a 5HT(3)antagonist. Five different total daily dexamethasone doses were administered in conjunction with a 5HT(3)antagonist to patients on day 1 of moderately emetogenic chemotherapy. Due to the heterogeneity of studies identified, meta-analysis was not possible. The optimal dexamethasone dose to control acute CIV and to minimize harms in pediatric patients remains uncertain. This is a key area for future research.

引用

页数：9

共 44 条

[1] RANDOMIZED DOUBLE-BLIND CROSSOVER ONDANSETRON-DEXAMETHASONE VERSUS ONDANSETRON-PLACEBO STUDY FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED NAUSEA AND VOMITING IN PEDIATRIC-PATIENTS WITH MALIGNANCIES [J].