Zinc-Mediated Palladium-Catalyzed Formation of Carbon-Sulfur Bonds

被引：141
作者：
Eichman, Chad C. [1 ]
Stambuli, James P. [1 ]
机构：
[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 10期
关键词：
CROSS-COUPLING REACTIONS; FORMING REDUCTIVE ELIMINATION; ARYL IODIDES; BORONIC ACIDS; S BOND; C-N; EFFICIENT; THIOLS; MECHANISM; HALIDES;
D O I：
10.1021/jo900385d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalytic amount of zinc chloride in combination with a palladium catalyst ligated by a monodentate phosphine allows the coupling of aryl and alkyl thiols with aryl bromides in high yields. The addition of zinc chloride to a palladium catalyst system that reportedly failed to promote sulfide formation allows this once ineffective catalyst system to provide the sulfide product in good yield. This paper describes a high-yielding and general monodentate phosphine-ligated palladium catalyst for biaryl and alkyl aryl sulfide formation.
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收藏
页码：4005 / 4008
页数：4
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