Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy

被引：1

作者：

Lee, So Jin ^{[1
]}

Min, Hyun Su ^{[1
]}

Ku, Sook Hee ^{[1
]}

Son, Sohee ^{[1
]}

Kwon, Ick Chan ^{[1
,2
]}

Kim, Sun Hwa ^{[1
]}

Kim, Kwangmeyung ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul 136791, South Korea

[2] Korea Univ, KU KIST Sch, Seoul 136701, South Korea

来源：

NANOMEDICINE | 2014年 / 9卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

amphiphilic nanoparticles; cancer therapy; diagnosis; EPR; glycol chitosan; SELF-ASSEMBLED NANOPARTICLES; DRUG-DELIVERY; POLYMERIC NANOPARTICLES; PHOTODYNAMIC THERAPY; ANTITUMOR EFFICACY; CELLULAR UPTAKE; IRON-OXIDE; SIRNA; NANOCARRIERS; DERIVATIVES;

D O I：

10.2217/NNM.14.99

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.

引用

页码：1697 / 1713

页数：17

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