Biocompatibility of various ferrite nanoparticles evaluated by in vitro cytotoxicity assays using HeLa cells

被引：114
作者：
Tomitaka, Asahi [1 ]
Hirukawa, Atsuo [1 ]
Yamada, Tsutomu [1 ]
Morishita, Shin [2 ]
Takemura, Yasushi [1 ]
机构：
[1] Yokohama Natl Univ, Dept Elect & Comp Engn, Kanagawa 2408501, Japan
[2] Yokohama Natl Univ, Dept Mech Engn & Mat Sci, Kanagawa 2408501, Japan
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期
关键词：
Magnetic nanoparticle; Hyperthermia; Biocompatibility; Cell adhesion; Viability; IRON-OXIDE NANOPARTICLES; COATED MAGNETITE NANOPARTICLES; BIOMEDICAL APPLICATIONS; CELLULAR UPTAKE; HYPERTHERMIA; ENHANCEMENT;
D O I：
10.1016/j.jmmm.2009.02.058
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Magnetic nanoparticles for thermotherapy must be biocompatible and possess high thermal efficiency as heating elements. The biocompatibility of Fe3O4 (20-30 nm), ZnFe2O4 (15-30nm) and NiFe2O4 (20-30 nm) nanoparticles was studied using a cytotoxicity colony formation assay and a cell viability assay. The Fe3O4 sample was found to be biocompatible on HeLa cells. While ZnFe2O4 and NiFe2O4 were non-toxic at low concentrations, HeLa cells exhibited cytotoxic effects when exposed to concentrations of 100 mg/ml nanoparticles. (c) 2009 Elsevier B.V.All rights reserved.
引用
收藏
页码：1482 / 1484
页数：3
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