Synthesis and crystal structure of cytisino-N-(2-hydroxyethyl)-thiocarbamide

被引：9

作者：

Kulakov, I. V. ^{[1
]}

Nurkenov, O. A. ^{[1
]}

Turdybekov, D. M. ^{[2
]}

Ainabaev, A. A. ^{[1
]}

Turdybekov, K. M. ^{[2
]}

Gazaliev, A. M. ^{[1
]}

机构：

[1] Kazakh Acad Sci, Inst Organ Synth & Coal Chem, Karaganda 100008, Kazakhstan

[2] Sci Prod Ctr Fitokhimiya, Karaganda, Kazakhstan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 01期

关键词：

alkaloid cytisine; acetal thiourea derivative; isothiocyanates; PMR spectroscopy; x-ray structure analysis; ALKALOIDS;

D O I：

10.1007/s10600-009-9251-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A thiourea derivative of the alkaloid cytisine was synthesized by reacting it with 1-propargyloxyethoxyethylisothiocyanate. It was shown that the synthesized acetal thiourea derivative underwent hydrolysis in acidic medium to cytisino-N-(2-hydroxyethyl)-thiocarbamide, the molecular structure of which was confirmed by an x-ray structure analysis.

引用

页码：66 / 68

页数：3

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