Endothelin Signaling in Bone

被引：7

作者：

Kristianto, Jasmin ^{[1
,2
,3
]}

Johnson, Michael G. ^{[4
]}

Afzal, Rafia ^{[5
]}

Blank, Robert D. ^{[1
,2
,3
,6
]}

机构：

[1] Med Coll Wisconsin, Dept Med, Div Endocrinol, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Med, Div Metab, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Med, Div Clin Nutr, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA

[4] Univ Wisconsin, Dept Med, 600 Highland Ave, Madison, WI 53792 USA

[5] Aga Khan Univ Hosp, Dept Anesthesiol, Stadium Rd, Karachi 74800, Pakistan

[6] Clement J Zablocki VAMC, Med Serv, 5000 West Natl Ave, Milwaukee, WI 53295 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2017年 / 46卷 / 01期

关键词：

WNT Signaling; Endothelin; 1; signaling; Osteogenesis; Mechanotransduction; Micro-RNA; RECEPTOR-RELATED PROTEIN-5; CONDUCTING PURKINJE-FIBERS; NITRIC-OXIDE PRODUCTION; PULSATILE SHEAR-STRESS; MESENCHYMAL STEM-CELLS; MINERAL DENSITY; CONVERTING ENZYME-1; B RECEPTOR; VASOCONSTRICTOR PEPTIDE; POSTMENOPAUSAL WOMEN;

D O I：

10.1016/j.ecl.2016.09.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The endothelin (ET) system includes 3 small peptide hormones and a pair of G-protein-coupled receptors. This review first outlines the ET signaling pathway and ET metabolism. Next, it summarizes the role of ET1 signaling in craniofacial development. Then, it discusses observations relating ET signaling to osteoblastic and other osteosclerotic processes in cancer. Finally, it describes recent work in our laboratory that points to endothelin signaling as an upstream mediator of WNT signaling, promoting bone matrix synthesis and mineralization. It concludes with a statement of some remaining gaps in knowledge and proposals for future research.

引用

页码：51 / +

页数：13

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