Total synthesis of pyridovericin: Studies toward the biomimetic synthesis of pyridomacrolidin

被引：34

作者：

Baldwin, JE

Adlington, RM

Conte, A

Irlapati, NR

Marquez, R

Pritchard, GJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Loughborough, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 13期

关键词：

D O I：

10.1021/ol0200504

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The total synthesis of the novel metabolite pyridovericin I is reported. The synthesis of this key intermediate in our proposed biomimetic synthesis of pyridomacrolidin 2 has been accomplished in good yield from readily available 2,4-dihydroxypyridine.

引用

页码：2125 / 2127

页数：3

共 24 条

[1] STRUCTURES OF THE CEPHALOSPOROLIDES B-F, A GROUP OF C-10 LACTONES FROM CEPHALOSPORIUM-APHIDICOLA
ACKLAND, MJ
HANSON, JR
HITCHCOCK, PB
RATCLIFFE, AH
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (04): : 843 - 847
[2] Highly efficient palladium-catalyzed boronic acid coupling reactions in water: Scope and limitations
Badone, D
Baroni, M
Cardamone, R
Ielmini, A
Guzzi, U
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (21) : 7170 - 7173
[3] LITHIATION OF 4-METHOXY-2-PYRIDONES - SYNTHETIC ENTRY TO TENELLIN AND FUNICULOSIN, AND RELATED NATURAL 3,5-DISUBSTITUTED 4-OXY-2-PYRIDONES
BUCK, J
MADELEY, JP
PATTENDEN, G
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (01): : 67 - 73
[4] DENHERTOG HJ, 1945, RECL TRAV CHIM PAY B, V64, P85
[5] ElBasyouni SH, 1968, CAN J BOT, V46, P441, DOI [DOI 10.1139/B68-067, 10.1139/b68-067]
[6] Practical asymmetric synthesis of (S)-4-ethyl-7,8-dihydro-4-hydroxy-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione, a key intermediate for the synthesis of irinotecan and other camptothecin analogs
Henegar, KE
Ashford, SW
Baughman, TA
Sih, JC
Gu, RL
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (19) : 6588 - 6597
[7] N-ALKENYL NITRONE DIPOLAR CYCLOADDITION ROUTES TO PIPERIDINES AND INDOLIZIDINES .5. PREPARATION OF A GEPHYROTOXIN PRECURSOR
HOLMES, AB
HUGHES, AB
SMITH, AL
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1993, (05): : 633 - 643
[8] SYNTHESIS ON 1,4-DIAMINOCYCLITOL ANTIBIOTICS .3. SYNTHESIS OF 4-HYDROXYPURPUROSAMINE-B DERIVATIVES
KANAI, K
SAKAMOTO, I
OGAWA, S
SUAMI, T
[J]. BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1987, 60 (04) : 1529 - 1531
[9] LEETE E, 1975, TETRAHEDRON LETT, P4103
[10] TYROSINE KINASE INHIBITION - AN APPROACH TO DRUG DEVELOPMENT
LEVITZKI, A
GAZIT, A
[J]. SCIENCE, 1995, 267 (5205) : 1782 - 1788

← 1 2 3 →