Pd(II)-Catalyzed Synthesis of Alkylidene Phthalides via a Decarbonylative Annulation Reaction

被引：23

作者：

Borthakur, Somadrita ^{[1
]}

Baruah, Swagata ^{[1
]}

Sarma, Bipul ^{[2
]}

Gogoi, Sanjib ^{[1
]}

机构：

[1] CSIR North East Inst Sci & Technol, Appl Organ Chem Chem Sci & Technol Div, AcSIR, Jorhat 785006, Assam, India

[2] Tezpur Univ, Dept Chem Sci, Tezpur 784028, India

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 08期

关键词：

GAMMA-BUTYROLACTONES; EFFICIENT APPROACH; FREDERICAMYCIN-A; LACTONES; CLEAVAGE;

D O I：

10.1021/acs.orglett.9b00726

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unprecedented Pd(II)-catalyzed decarbonylative C-H/C-C activation and annulation reaction, which proceeds via intramolecular cyclization, is reported. This reaction of hydroxynaphthoquinones with disubstituted alkynes provides good yields of substituted alkylidene phthalides, which are the key intermediates for the synthesis of bioactive natural products.

引用

页码：2768 / 2771

页数：4

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