Closing in on the cause of insulin resistance and type 2 diabetes

被引：12
作者：
Brady, MJ [1 ]
Saltiel, AR [1 ]
机构：
[1] Warner Lambert Co, Parke Davis Pharmaceut Res Div, Dept Cell Biol, Ann Arbor, MI 48105 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 1999年 / 104卷 / 06期
关键词：
D O I：
10.1172/JCI8216
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：675 / 676
页数：2
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共 8 条
[1]   Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes [J].
Cline, GW ;
Petersen, KF ;
Krssak, M ;
Shen, J ;
Hundal, RS ;
Trajanoski, Z ;
Inzucchi, S ;
Dresner, A ;
Rothman, DL ;
Shulman, GI .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :240-246
[2]   Signaling mechanisms that regulate glucose transport [J].
Czech, MP ;
Corvera, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (04) :1865-1868
[3]   Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate [J].
Jiang, T ;
Sweeney, G ;
Rudolf, MT ;
Klip, A ;
Traynor-Kaplan, A ;
Tsien, RY .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (18) :11017-11024
[4]   FACILITATIVE GLUCOSE TRANSPORTERS - REGULATORY MECHANISMS AND DYSREGULATION IN DIABETES [J].
KAHN, BB .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (05) :1367-1374
[5]   Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes [J].
Kim, YB ;
Nikoulina, SE ;
Ciaraldi, TP ;
Henry, RR ;
Kahn, BB .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (06) :733-741
[6]   Synip: A novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes [J].
Min, J ;
Okada, S ;
Kanzaki, M ;
Elmendorf, JS ;
Coker, KJ ;
Ceresa, BP ;
Syu, LJ ;
Noda, Y ;
Saltiel, AR ;
Pessin, JE .
MOLECULAR CELL, 1999, 3 (06) :751-760
[7]   Molecular basis of insulin-stimulated GLUT4 vesicle trafficking - Location! Location! Location! [J].
Pessin, JE ;
Thurmond, DC ;
Elmendorf, JS ;
Coker, KJ ;
Okada, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (05) :2593-2596
[8]   Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes - Potential role in glucose transport [J].
Standaert, ML ;
Galloway, L ;
Karnam, P ;
Bandyopadhyay, G ;
Moscat, J ;
Farese, RV .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) :30075-30082
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