Pioneer Factors and Architectural Proteins Mediating Embryonic Expression Signatures in Cancer

被引：20

作者：

Dobersch, Stephanie ^{[1
]}

Rubio, Karla ^{[1
]}

Barreto, Guillermo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Max Planck Inst Heart & Lung Res, Lung Canc Epigenet, D-61231 Bad Nauheim, Germany

[2] Univ Paris Est, Univ Paris Est Creteil, Lab Croissance Reparat & Regenerat Tissulaires CR, CNRS,ERL 9215, F-94000 Creteil, France

[3] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, Kazan 420008, Russia

[4] UGMLC, ECCPS, D-35932 Giessen, Germany

[5] DZL, German Ctr Lung Res, Giessen, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 04期

关键词：

MOBILITY GROUP PROTEIN-14; TRANSCRIPTION FACTORS; REGULATORY ELEMENTS; STEM-CELLS; MESENCHYMAL TRANSITION; COMPACTED CHROMATIN; HISTONE VARIANTS; TUMOR-SUPPRESSOR; GENE-EXPRESSION; PBX HOMEODOMAIN;

D O I：

10.1016/j.molmed.2019.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin rearrangements initiated by pioneer factors and architectural proteins are key events occurring before cancer-related genes are expressed. Both protein groups are also master regulators of important processes during embryogenesis. Several publications demonstrated that embryonic gene expression signatures are reactivated during cancer. This review article highlights current knowledge on pioneer factors and architectural proteins mediating chromatin rearrangements, which are the backbone of embryonic expression signatures promoting malignant transformation. Understanding chromatin rearrangements inducing embryonic expression signatures in adult cells might be the key to novel therapeutic approaches against cancers subtypes that arise without genomic mutations.

引用

页码：287 / 302

页数：16

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