Immunosenescence: what does it mean to health outcomes in older adults?

被引：250

作者：

McElhaney, Janet E. ^{[1
,2
]}

Effros, Rita B. ^{[3
]}

机构：

[1] Univ British Columbia, Dept Med, Vancouver, BC V6Z 1Y6, Canada

[2] Univ Connecticut, Sch Med, Ctr Immunotherapy Canc & Infect Dis, Farmington, CT 06030 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

T-CELL REPERTOIRE; REPEATED INFLUENZA VACCINATION; SWEDISH NONA IMMUNE; CLONAL EXPANSIONS; REPLICATIVE SENESCENCE; CYTOKINE PRODUCTION; VIRUS INFECTION; AGE; EXPRESSION; PHENOTYPE;

D O I：

10.1016/j.coi.2009.05.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The most profound consequences of immune senescence with respect to human health are the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes in both innate and adaptive immune function converge in the reduced response to vaccination and protection against infection and related diseases. The decline in thymic output of naive T cells diminishes responses to novel antigens, such as West Nile Virus, while clonal expansions leading to defects in the T cell repertoire are associated with blunted responses of memory T cells to conserved epitopes of the influenza virus. Recent studies on how immunologic mechanisms of protection change during aging have led to novel strategies for improving vaccine responsiveness and outcomes of infectious diseases in older adults.

引用

页码：418 / 424

页数：7

共 47 条

[1] Biology of dendritic cells in aging [J].

Agrawal, Anshu ;

Agrawal, Sudhanshu ;

Tay, Jia ;

Gupta, Sudhir .

JOURNAL OF CLINICAL IMMUNOLOGY, 2008, 28 (01) :14-20

[2] Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice [J].

Ahmed, Mushtaq ;

Lanzer, Kathleen G. ;

Yager, Eric J. ;

Adams, Pamela S. ;

Johnson, Lawrence L. ;

Blackman, Marcia A. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (02) :784-792

[3] Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons [J].

Almanzar, G ;

Schwaiger, S ;

Jenewein, B ;

Keller, M ;

Herndler-Brandstetter, D ;

Würzner, R ;

Schönitzer, D ;

Grubeck-Loebenstein, B .

JOURNAL OF VIROLOGY, 2005, 79 (06) :3675-3683

[4] Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression [J].

Alter-Wolf, Sarah ;

Blomberg, Bonnie B. ;

Riley, Richard L. .

JOURNAL OF IMMUNOLOGY, 2009, 182 (01) :138-147

[5] Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections [J].

Appay, V ;

Dunbar, PR ;

Callan, M ;

Klenerman, P ;

Gillespie, GMA ;

Papagno, L ;

Ogg, GS ;

King, A ;

Lechner, F ;

Spina, CA ;

Little, S ;

Havlir, DV ;

Richman, DD ;

Gruener, N ;

Pape, G ;

Waters, A ;

Easterbrook, P ;

Salio, M ;

Cerundolo, V ;

McMichael, AJ ;

Rowland-Jones, SL .

NATURE MEDICINE, 2002, 8 (04) :379-385

[6] Reversal of age-associated thymic atrophy: Treatments, delivery, and side effects [J].

Aspinall, Richard ;

Mitchell, Wayne .

EXPERIMENTAL GERONTOLOGY, 2008, 43 (07) :700-705

[7] Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination [J].

Aspinall, Richard ;

Pido-Lopez, Jeffrey ;

Imami, Nesrina ;

Henson, Sian M. ;

Ngom, Pa Tamba ;

Morre, Michel ;

NiphuiS, Henk ;

Remarque, Ed ;

Rosenwirth, Brigitte ;

Heeney, Jonathan L. .

REJUVENATION RESEARCH, 2007, 10 (01) :5-17

[8] Premature Aging of T cells Is Associated With Faster HIV-1 Disease Progression [J].

Cao, Weiwei ;

Jamieson, Beth D. ;

Hultin, Lance E. ;

Hultin, Patricia M. ;

Effros, Rita B. ;

Detels, Roger .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2009, 50 (02) :137-147

[9] CD8 T cell clonal expansions & aging: A heterogeneous phenomenon with a common outcome [J].

Clambey, Eric T. ;

Kappler, John W. ;

Marrack, Philippa .

EXPERIMENTAL GERONTOLOGY, 2007, 42 (05) :407-411

[10] Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties [J].

Clamby, Eric T. ;

White, Janice ;

Kappler, John W. ;

Marrack, Philippa .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :12997-13002

← 1 2 3 4 5 →