Hemoglobin-based red blood cell substitutes

被引:63
作者
Chang, TMS [1 ]
机构
[1] McGill Univ, Fac Med, MSSS FRSQ Res Grp Blood Substitutes Transfus Med, Artificial Cells & Organs Res Ctr, Montreal, PQ H3G 1Y6, Canada
关键词
red blood cell substitutes; artificial blood; polyhemoglobin; conjugated hemoglobin; recombinant hemoglobin; hemoglobin-lipid vesicles; nanotechnology; biodegradable copolymers; oxygen therapeutics;
D O I
10.1111/j.1525-1594.2004.07394.x
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Polyhemoglobin is already well into the final stages of clinical trials in humans with one approved for routine clinical use in South Africa. Conjugated hemoglobin is also in ongoing clinical trials. Meanwhile, recombinant Hb has been modified to modulate the effects of nitric oxide. Other systems contain antioxidant enzymes for those clinical applications that may have potential problems related to ischemia-reperfusion injuries. Other developments are based on hemoglobin-lipid vesicles and also the use of nanotechnology and biodegradable copolymers to prepare nanodimension artificial red blood cells containing hemoglobin and complex enzyme systems.
引用
收藏
页码:789 / 794
页数:6
相关论文
共 48 条
[1]  
Adamson JG, 1998, TISS ENG, P62
[2]   Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants? [J].
Alayash, AI .
NATURE BIOTECHNOLOGY, 1999, 17 (06) :545-549
[3]   Blood substitutes [J].
Amberson, WR .
BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY, 1937, 12 (01) :48-86
[4]   Resuscitative effects of polynitroxylated αα-cross-linked hemoglobin following severe hemorrhage in the rat [J].
Buehler, PW ;
Mehendale, S ;
Wang, HS ;
Xie, JT ;
Ma, L ;
Trimble, CE ;
Hsia, CJC ;
Gulati, A .
FREE RADICAL BIOLOGY AND MEDICINE, 2000, 29 (08) :764-774
[5]  
Bunn H F, 1968, Trans Assoc Am Physicians, V81, P147
[6]  
Carmichael FJL, 2001, TRANSFUS APHER SCI, V24, P17
[7]  
Chang T., 1997, US Pat, Patent No. 5670173
[8]   Future generations of red blood cell substitutes [J].
Chang, TMS .
JOURNAL OF INTERNAL MEDICINE, 2003, 253 (05) :527-535
[9]  
CHANG TMS, 1988, BIOMATER ARTIF CELL, V16, P1
[10]   SEMIPERMEABLE MICROCAPSULES CONTAINING CATALASE FOR ENZYME REPLACEMENT IN ACATALASAEMIC MICE [J].
CHANG, TMS ;
POZNANSKY, MJ .
NATURE, 1968, 218 (5138) :243-+