SYNTHESIS, LARVICIDAL AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITIES OF CARVACROL/THYMOL AND DERIVATIVES

被引：19

作者：

de Mesquita, Bruna M. ^{[1
]}

do Nascimento, Patricia G. G. ^{[1
]}

Souza, Luciana G. S. ^{[1
]}

de Farias, Iolanda F. ^{[1
]}

da Silva, Romezio A. C. ^{[1
]}

de Lemos, Telma L. G. ^{[1
]}

Monte, Francisco J. Q. ^{[1
]}

Oliveira, Irvila R. ^{[1
]}

Trevisan, Maria T. S. ^{[1
]}

da Silva, Horlando C. ^{[1
]}

Santiago, Gilvandete M. P. ^{[2
]}

机构：

[1] Univ Fed Ceara, Dept Quim Organ & Inorgan, Campus Pici, BR-60021940 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Farm, Campus Porangabussu, BR-60430370 Fortaleza, Ceara, Brazil

来源：

QUIMICA NOVA | 2018年 / 41卷 / 04期

关键词：

carvacrol; thymol; acetylcholinesterase; Aedes aegypti; AEDES-AEGYPTI LARVAE; ESSENTIAL OILS; ANTIFUNGAL ACTIVITY; DIPTERA-CULICIDAE; IDENTIFICATION; BIOACTIVITY; ACETATE; PLANTS; FUNGI; MICE;

D O I：

10.21577/0100-4042.20170189

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a,2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC50 values of 23.60 ppm, considered a very good result.

引用

页码：412 / 416

页数：5

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