Apoptosis in the Colonic Crypt, Colorectal Adenomata, and Manipulation by Chemoprevention

被引：28

作者：

West, Nicholas J. ^{[1
]}

Courtney, Edward D. J. ^{[1
]}

Poullis, Andrew P. ^{[1
]}

Leicester, Roger J. ^{[1
]}

机构：

[1] St George Hosp, Endoscopy Dept, London SW17 OQT, England

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2009年 / 18卷 / 06期

关键词：

RECTAL EPITHELIAL APOPTOSIS; PROGRAMMED CELL-DEATH; IN-SITU DETECTION; FISH-OIL; DNA FRAGMENTATION; FAMILY-HISTORY; BCL-2; FAMILY; TUNEL ASSAY; RAT COLON; PROLIFERATION;

D O I：

10.1158/1055-9965.EPI-09-0006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1680-7)

引用

页码：1680 / 1687

页数：8

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