Eco-friendly one pot synthesis of caffeic acid phenethyl ester (CAPE) via an in-situ formed deep eutectic solvent

被引：12
作者：
Fischer, Veronika [1 ]
Touraud, Didier [1 ]
Kunz, Werner [1 ]
机构：
[1] Univ Regensburg, Fac Chem & Pharm, D-93040 Regensburg, Germany
来源：
SUSTAINABLE CHEMISTRY AND PHARMACY | 2016年 / 4卷
关键词：
Caffeic acid phenethyl ester; Deep eutectic solvent; Green synthesis; Green solvent; Miscibility; One pot synthesis; CHOLINE-CHLORIDE; GREEN EXTRACTION; NATURAL-PRODUCTS; TUMOR PROMOTION; IONIC LIQUIDS; MOUSE SKIN; PROPOLIS; ESTERIFICATION; AMBERLYST-15; MEDIA;
D O I：
10.1016/j.scp.2016.08.002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this paper, a new strategy towards the synthesis of caffeic acid phenethyl ester (CAPE) is introduced. The reaction is carried out in a deep eutectic solvent made of caffeic acid and choline chloride. Caffeic acid is used as part of the solvent and as reactant. Phenethyl alcohol is soluble in this mixture in every molar ratio, and as a consequence no additional solvent is necessary. Reaction conditions were optimised with respect to the molar ratio of phenethyl alcohol and caffeic acid, and by varying the amount and nature of the acid catalyst as well as the reaction time. The obtained CAPE ester could easily be separated from the reaction mixture by simply adding water to destroy the deep eutectic by solubilisation of choline chloride in the aqueous phase. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：40 / 45
页数：6
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