Synthesis and Self-Assembly of Thermosensitive Double-Hydrophilic Poly(N-vinylcaprolactam)-b-poly(N-vinyl-2-pyrrolidone) Diblock Copolymers

被引：43

作者：

Liang, Xing ^{[1
]}

Kozlovskaya, Veronika ^{[1
]}

Cox, Christopher P. ^{[1
]}

Wang, Yun ^{[1
]}

Saeed, Mohammad ^{[2
]}

Kharlampieva, Eugenia ^{[1
,3
]}

机构：

[1] Univ Alabama Birmingham, Dept Chem, Birmingham, AL 35294 USA

[2] So Res Inst, Dept Biochem & Mol Biol, Drug Discovery Div, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Ctr Nanoscale Mat & Biointegrat, Birmingham, AL 35294 USA

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2014年 / 52卷 / 19期

基金：

美国国家科学基金会;

关键词：

biopolymers; block copolymers; diblock copolymers; micelles; poly(N-vinylcaprolactam); poly(N-vinylpyrrolidone); radical polymerization; RAFT polymerization; stimulisensitive polymers; temperature-responsive; CONTROLLED RADICAL POLYMERIZATION; BLOCK-COPOLYMERS; MOLECULAR-WEIGHT; RESWELLING BEHAVIOR; TRIBLOCK COPOLYMERS; RAFT POLYMERIZATION; N-VINYLCAPROLACTAM; POLY(N-VINYLCAPROLACTAM); POLY(N-ISOPROPYLACRYLAMIDE); XANTHATE;

D O I：

10.1002/pola.27291

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report on novel diblock copolymers of poly(N-vinylcaprolactam) (PVCL) and poly(N-vinyl-2-pyrrolidone) (PVPON) (PVCL-b-PVPON) with well-defined block lengths synthesized by the MADIX/reversible addition-fragmentation chain transfer (RAFT) process. We show that the lower critical solution temperatures (LCST) of the block copolymers are controllable over the length of PVCL and PVPON segments. All of the diblock copolymers dissolve molecularly in aqueous solutions when the temperature is below the LCST and form spherical micellar or vesicular morphologies when temperature is raised above the LCST. The size of the self-assembled structures is controlled by the molar ratio of PVCL and PVPON segments. The synthesized homopolymers and diblock copolymers are demonstrated to be nontoxic at 0.1-1 mg mL(-1) concentrations when incubated with HeLa and HEK293 cancer cells for various incubation times and have potential as nanovehicles for drug delivery. (C) 2014 Wiley Periodicals, Inc.

引用

页码：2725 / 2737

页数：13

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