Genetics of endometriosis: heritability and candidate genes

被引：41
作者：
Bischoff, F [1 ]
Simpson, JL [1 ]
机构：
[1] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY | 2004年 / 18卷 / 02期
关键词：
candidate genes; endometriosis; heritability; multihit;
D O I：
10.1016/j.bpobgyn.2004.01.004
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Endometriosis is a complex gynecologic disorder that affects as many as 10-15% of premenopausal women. Epidemiologic studies have confirmed that this disease is a genetic disorder of polygenic/multifactorial inheritance. The disorder has long been recognized to show heritable tendencies with recurrence risks of 5-7% for first-degree relatives. The current investigational goal is to determine the number and location of causative genes, a process that has been made possible by recent advances in molecular technology. This chapter discusses heritability studies supporting polygenic/multifactorial inheritance, the scientific basis of genome-wide strategies for identifying causative genes and potential candidate genes.
引用
收藏
页码：219 / 232
页数：14
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