Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

被引：11
作者：
Li, Ranwei [2 ]
Liu, Tiecheng [3 ]
Wang, Ke [1 ]
机构：
[1] Jilin Univ, Affiliated Hosp 2, Dept Resp Med, Changchun 130041, Jilin, Peoples R China
[2] Jilin Univ, Affiliated Hosp 2, Dept Urinary Surg, Changchun 130041, Jilin, Peoples R China
[3] Jilin Univ, Affiliated Hosp 2, Dept Anesthesiol, Changchun 130041, Jilin, Peoples R China
来源：
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2017年 / 62卷 / 01期
关键词：
hyaluronic acid; lung cancer; paclitaxel; zirco-nium phosphate; NANO-SYSTEM; CO-DELIVERY; DRUG; MICELLES; GENE;
D O I：
10.1515/bmt-2015-0238
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Novel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%+/- 4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity in vitro. In vivo anticancer efficacy assay revealed that HA-ZP nanoparticles possessed preferable anticancer abilities, which exhibited minimized toxic side effects of PTX and strong tumor-suppression potential in clinical application.
引用
收藏
页码：67 / 73
页数：7
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