Tepotinib for advanced non-small-cell lung cancer with MET exon 14 skipping mutations

被引：4

作者：

Blaszkowska, M. ^{[1
]}

Specht-Szwoch, Z. ^{[1
]}

Dziadziuszko, R. ^{[1
,2
]}

机构：

[1] Med Univ Gdansk, Early Clin Trials Ctr, Gdansk, Poland

[2] Med Univ Gdansk, Dept Oncol & Radiotherapy, Gdansk, Poland

来源：

ESMO OPEN | 2022年 / 7卷 / 02期

关键词：

D O I：

10.1016/j.esmoop.2022.100449

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：2

共 9 条

[1]

European Medicines Agency, TEPM

[2] First-in-Man Phase I Trial of the Selective MET Inhibitor Tepotinib in Patients with Advanced Solid Tumors [J].

Falchook, Gerald S. ;

Kurzrock, Razelle ;

Amin, Hesham M. ;

Xiong, Wenyuan ;

Fu, Siqing ;

Piha-Paul, Sarina A. ;

Janku, Filip ;

Eskandari, Ghazaleh ;

Catenacci, Daniel V. ;

Klevesath, Manfred ;

Bruns, Rolf ;

Stammberger, Uz ;

Johne, Andreas ;

Bladt, Friedhelm ;

Friese-Hamim, Manja ;

Girard, Pascal ;

El Bawab, Samer ;

Hong, David S. .

CLINICAL CANCER RESEARCH, 2020, 26 (06) :1237-1246

[3] The METeoric rise of MET in lung cancer [J].

Friedlaender, Alex ;

Drilon, Alexander ;

Banna, Giuseppe Luigi ;

Peters, Solange ;

Addeo, Alfredo .

CANCER, 2020, 126 (22) :4826-4837

[4] Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases [J].

Friese-Hamim, Manja ;

Clark, Anderson ;

Perrin, Dominique ;

Crowley, Lindsey ;

Reusch, Christof ;

Bogatyrova, Olga ;

Zhang, Hong ;

Crandall, Timothy ;

Lin, Jing ;

Ma, Jianguo ;

Bachner, David ;

Schmidt, Jurgen ;

Schaefer, Martin ;

Stroh, Christopher .

LUNG CANCER, 2022, 163 :77-86

[5] FDA Approval Summary: Capmatinib and Tepotinib for the Treatment of Metastatic NSCLC Harboring MET Exon 14 Skipping Mutations or Alterations [J].

Mathieu, Luckson N. ;

Larkins, Erin ;

Akinboro, Oladimeji ;

Roy, Pourab ;

Amatya, Anup K. ;

Fiero, Mallorie H. ;

Mishra-Kalyani, Pallavi S. ;

Helms, Whitney S. ;

Myers, Claire E. ;

Skinner, Amy M. ;

Aungst, Stephanie ;

Jin, Runyan ;

Zhao, Hong ;

Xia, Huiming ;

Zirkelbach, Jeanne Fourie ;

Bi, Youwei ;

Li, Yangbing ;

Liu, Jiang ;

Grimstein, Manuela ;

Zhang, Xinyuan ;

Woods, Stacie ;

Reece, Kelie ;

Abukhdeir, Abdelrahmman M. ;

Ghosh, Soma ;

Philip, Reena ;

Tang, Shenghui ;

Goldberg, Kirsten B. ;

Pazdur, Richard ;

Beaver, Julia A. ;

Singh, Harpreet .

CLINICAL CANCER RESEARCH, 2022, 28 (02) :249-254

[6]

National Comprehensive Cancer Network, NONSM CELL LUNG CANC

[7] Tepotinib in Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations [J].

Paik, Paul K. ;

Felip, Enriqueta ;

Veillon, Remi ;

Sakai, Hiroshi ;

Cortot, Alexis B. ;

Garassino, Marina C. ;

Mazieres, Julien ;

Viteri, Santiago ;

Senellart, Helene ;

Van Meerbeeck, Jan ;

Raskin, Jo ;

Reinmuth, Niels ;

Conte, Pierfranco ;

Kowalski, Dariusz ;

Cho, Byoung Chul ;

Patel, Jyoti D. ;

Horn, Leora ;

Griesinger, Frank ;

Han, Ji-Youn ;

Kim, Young-Chul ;

Chang, Gee-Chen ;

Tsai, Chen-Liang ;

Yang, James C. -H. ;

Chen, Yuh-Min ;

Smit, Egbert F. ;

van der Wekken, Anthonie J. ;

Kato, Terufumi ;

Juraeva, Dilafruz ;

Stroh, Christopher ;

Bruns, Rolf ;

Straub, Josef ;

Johne, Andreas ;

Scheele, Juergen ;

Heymach, John V. ;

Le, Xiuning .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (10) :931-943

[8]

U.S. Food and Drug Administration, FDA GRANTS ACC APPR

[9] Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo [J].

Vagiannis, Dimitrios ;

Budagaga, Youssif ;

Morell, Anselm ;

Zhang, Yu ;

Novotna, Eva ;

Skarka, Adam ;

Kammerer, Sarah ;

Kupper, Jan-Heiner ;

Hanke, Ivo ;

Rozkos, Tomas ;

Hofman, Jakub .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)

← 1 →