Lipid rafts: microenvironments for integrin-growth factor interactions in neural development

被引：40
作者：
Decker, L
Baron, W
ffrench-Constant, C
机构：
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
[2] Univ Cambridge, Dept Med Genet, Cambridge CB2 1QP, England
[3] Univ Cambridge, Cambridge Ctr Brain Repair, Cambridge CB2 1QP, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2004年 / 32卷
关键词：
apoptosis; laminin; oligodendrocyte; platelet-derived growth factor (PDGF);
D O I：
10.1042/BST0320426
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of a complex multicellular organ such as the nervous system requires precise regulation of cell migration, proliferation and survival. This regulation in turn requires the integration of long-range signals, such as growth factors, with short-range cues that define the precise location and cellular neighbours for any given cell. This short review examines one integrative mechanism, integrin-growth factor receptor interactions, and explores the role of lipid rafts in the molecular mechanisms that underlie the receptor interactions.
引用
收藏
页码：426 / 430
页数：5
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