Utility of HBME-1 immunostaining in serous effusions

被引：18

作者：

Ascoli, V

CarnovaleScalzo, C

Taccogna, S

Nardi, F

机构：

[1] Laboratorio di Citodiagnostica, Dipto. di Medicina Sperimentale, Università 'La Sapienza', Roma

[2] Laboratorio di Citodiagnostica, Dipto. di Medicina Sperimentale, VI Servizio di Anatoma Patologica, 00161 Rome

来源：

CYTOPATHOLOGY | 1997年 / 8卷 / 05期

关键词：

cancer-related antigens; immunocytochemistry adenocarcinoma; mesothelioma; mesothelial cells; cytodiagnosis; effusion;

D O I：

10.1111/j.1365-2303.1997.tb00557.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HBME-1 is an anti-mesothelial cell monoclonal antibody derived from human mesothelioma cells, We investigated 227 body cavity effusions to test its utility in differentiating mesothelioma from adenocarcinoma. HBME-1 outlined cell membranes in non-neoplastic mesothelial cells. Thick surface staining was observed on all mesotheliomas. HBME-1 reactivity was also detected in 24% of metastatic carcinomatous effusions, Most ovarian carcinomas (83%) reacted with this antibody, showing surface staining, Cytoplasmic HBME-1 immunoreactivity was observed in a small proportion of non-ovarian adenocarcinomas (14%). Despite its limited specificity, HBME-1 might be added to the battery of other markers of epithelial and/or mesothelial differentiation to be used in cases of suspected mesothelioma, Evaluation of suspicious cells should include careful study of the pattern of immunostaining.

引用

页码：328 / 335

页数：8

共 22 条

[1] UTILITY OF CYTOKERATIN 20 IN IDENTIFYING THE ORIGIN OF METASTATIC CARCINOMAS IN EFFUSIONS [J].