Mixed large cell neuroendocrine carcinoma and adenosquamous carcinoma of gallbladder: a case report

Here we present an extremely rare case of mixed large cell neuroendocrine carcinoma and adenosquamous carcinoma of gallbladder. The patient was a 52-year-old Chinese male who was admitted to our hospital twice. Because of severe adhesion obscuring the Calot's triangle, the patient went through cholecystostomy and biopsy of the wall of the gallbladder instead of cholecystectomy in the first admission. Pathological results showed inflammatory changes without tumor cells. The patient was readmitted to our hospital for cholecystectomy as the infection was relieved 3 months later. The pathological results confirmed adenocarcinoma (accounted for about 40%) with squamous cell carcinoma (accounted for about 50%) and large cell neuroendocrine carcinoma (accounted for about 10%), with Ki-67 labeling index 80%. The patient underwent an uneventful postoperative course and then received chemotherapy with gemcitabine/oxaliplatin, he would be followed up every 3 weeks.