Cutting Edge: Parathyroid Hormone Facilitates Macrophage Efferocytosis in Bone Marrow via Proresolving Mediators Resolvin D1 and Resolvin D2

被引：45

作者：

McCauley, Laurie K. ^{[1
,2
]}

Dalli, Jesmond ^{[3
]}

Koh, Amy J. ^{[1
]}

Chiang, Nan ^{[3
]}

Serhan, Charles N. ^{[3
]}

机构：

[1] Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[3] Brigham & Womens Hosp, Harvard Inst Med, Ctr Expt Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat & Pain Med, Boston, MA 02115 USA

来源：

JOURNAL OF IMMUNOLOGY | 2014年 / 193卷 / 01期

基金：

美国国家卫生研究院;

关键词：

HUMAN PHAGOCYTES; LIPID MEDIATORS; CELLS; TERIPARATIDE; INFLAMMATION; RESOLUTION; EXPRESSION; INCREASE;

D O I：

10.4049/jimmunol.1301945

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by poorly defined mechanisms. Specialized proresolving mediators of inflammation drive macrophage efferocytosis (phagocytosis of apoptotic cells) and resolution, but little is known regarding this process in the bone marrow. In this study, metabololipidomic profiling via liquid chromatography mass spectrometry revealed higher levels of specialized proresolving mediators in the bone marrow relative to the spleen. The endocrine and bone anabolic agent parathyroid hormone increased specialized proresolving mediator levels, including resolvins (Rvs), in bone marrow. Human and murine primary macrophages efferocytosed apoptotic osteoblasts in vitro, and RvD1 and RvD2 (10 pM-10 nM) enhanced this process. These findings support a unique profile of specialized lipid mediators in bone marrow that contribute to a feedback system for resolution of inflammation and maintenance of skeletal homeostasis.

引用

页码：26 / 29

页数：4

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