Thick ascending limb: the Na+:K+:2Cl- co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

被引：88
作者：
Gamba, Gerardo [1 ,2 ]
Friedman, Peter A. [3 ]
机构：
[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mol Physiol Unit, Mexico City, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 14000, DF, Mexico
[3] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Diuretics; Hypertension; Salt transport; Regulation; Phosphorylation; Isoforms; K-CL COTRANSPORTER; EXTRACELLULAR CA2+-SENSING RECEPTOR; RENAL NA+-K+-2CL(-) COTRANSPORTER; CATION-CHLORIDE-COTRANSPORTERS; INCREASES SURFACE EXPRESSION; ANTENATAL BARTTER-SYNDROME; MEDULLARY COLLECTING DUCT; BOVINE PARATHYROID CELLS; DISTAL CONVOLUTED TUBULE; AMINO-ACID-SEQUENCE;
D O I：
10.1007/s00424-008-0607-1
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na+:K+:2Cl(-) co-transporter, the K+ channel, and basolateral Cl- channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca2+ and Mg2+ absorption. Calcium-sensing receptor activation inhibits cellular Ca2+ absorption induced by parathyroid hormone, as well as passive paracellular Ca2+ transport. The present review discusses these functions and their genetic and molecular regulation.
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收藏
页码：61 / 76
页数：16
相关论文
共 161 条
  • [1] CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism
    Abdullah, Huda Ismail
    Pedraza, Paulina L.
    McGiff, John C.
    Ferreri, Nicholas R.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2008, 294 (02) : F345 - F354
  • [2] Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1
    Adachi, Masanori
    Asakura, Yumi
    Sato, Yosh. Iaki
    Tajima, Toshihiro
    Nakajima, Takeo
    Yamamoto, Toshiyuki
    Fujieda, Kenji
    [J]. ENDOCRINE JOURNAL, 2007, 54 (06) : 1003 - 1007
  • [3] Na+-K+(NH4+)-2Cl(-) cotransport in medullary thick ascending limb: Control by PKA, PKC, and 20-HETE
    Amlal, H
    Legoff, C
    Vernimmen, C
    Paillard, M
    Bichara, M
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1996, 271 (02): : C455 - C463
  • [4] Specific coupling of a cation-sensing receptor to G protein alpha-subunits in MDCK cells
    Arthur, JM
    Collinsworth, GP
    Gettys, TW
    Quarles, LD
    Raymond, JR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1997, 273 (01) : F129 - F135
  • [5] THE ROLE OF N-GLYCOSYLATION IN THE TARGETING AND STABILITY OF GLUT1 GLUCOSE-TRANSPORTER
    ASANO, T
    TAKATA, K
    KATAGIRI, H
    ISHIHARA, H
    INUKAI, K
    ANAI, M
    HIRANO, H
    YAZAKI, Y
    OKA, Y
    [J]. FEBS LETTERS, 1993, 324 (03) : 258 - 261
  • [6] Stimulation by in vivo and in vitro metabolic acidosis of expression of rBSC-1, the Na+-K+(NH4+)-2Cl- cotransporter of the rat medullary thick ascending limb
    Attmane-Elakeb, A
    Mount, DB
    Sibella, V
    Vernimmen, C
    Hebert, SC
    Bichara, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) : 33681 - 33691
  • [7] Regulation by glucocorticoids of expression and activity of rBSC1, the Na+-K+ (NH4+)-2Cl- cotransporter of medullary thick ascending limb
    Attmane-Elakeb, A
    Sibella, V
    Vernimmen, C
    Belenfant, X
    Hebert, SC
    Bichara, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (43) : 33548 - 33553
  • [8] Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
    Bai, M
    Trivedi, S
    Brown, EM
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (36) : 23605 - 23610
  • [9] Bartter FC, 1998, J AM SOC NEPHROL, V9, P516
  • [10] NKCC2 surface expression in mammalian cells - down-regulation by novel interaction with aldolase b
    Benziane, Boubacar
    Demaretz, Sylvie
    Defontaine, Nadia
    Zaarour, Nancy
    Cheval, Lydie
    Bourgeois, Soline
    Klein, Christophe
    Froissart, Marc
    Blanchard, Anne
    Paillard, Michel
    Gamba, Gerardo
    Houillier, Pascal
    Laghmani, Kamel
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (46) : 33817 - 33830
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