Thick ascending limb: the Na+:K+:2Cl- co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

被引：92

作者：

Gamba, Gerardo ^{[1
,2
]}

Friedman, Peter A. ^{[3
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mol Physiol Unit, Mexico City, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City 14000, DF, Mexico

[3] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15261 USA

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2009年 / 458卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Diuretics; Hypertension; Salt transport; Regulation; Phosphorylation; Isoforms; K-CL COTRANSPORTER; EXTRACELLULAR CA2+-SENSING RECEPTOR; RENAL NA+-K+-2CL(-) COTRANSPORTER; CATION-CHLORIDE-COTRANSPORTERS; INCREASES SURFACE EXPRESSION; ANTENATAL BARTTER-SYNDROME; MEDULLARY COLLECTING DUCT; BOVINE PARATHYROID CELLS; DISTAL CONVOLUTED TUBULE; AMINO-ACID-SEQUENCE;

D O I：

10.1007/s00424-008-0607-1

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The thick ascending limb of Henle's loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na+:K+:2Cl(-) co-transporter, the K+ channel, and basolateral Cl- channel that mediate electroneutral salt absorption. In thick ascending limbs, salt absorption is importantly regulated by the calcium-sensing receptor. Genetic or pharmacological disruption impairing the function of any of these proteins results in Bartter syndrome. The thick ascending limb is also an important site of Ca2+ and Mg2+ absorption. Calcium-sensing receptor activation inhibits cellular Ca2+ absorption induced by parathyroid hormone, as well as passive paracellular Ca2+ transport. The present review discusses these functions and their genetic and molecular regulation.

引用

页码：61 / 76

页数：16

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