A systems biology approach to identify intelligence quotient score-related genomic regions, and pathways relevant to potential therapeutic treatments

被引：8
作者：
Zhao, Min [1 ]
Kong, Lei [1 ]
Qu, Hong [1 ]
机构：
[1] Peking Univ, Coll Life Sci, Ctr Bioinformat, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
来源：
SCIENTIFIC REPORTS | 2014年 / 4卷
基金：
中国国家自然科学基金;
关键词：
DEPENDENT PROTEIN-KINASE; SIGNALING PATHWAYS; SEX DIFFERENCE; IQ; GENES; INVOLVEMENT; DISRUPTION; DOPAMINE; CANCER; TRAIT;
D O I：
10.1038/srep04176
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Although the intelligence quotient (IQ) is the most popular intelligence test in the world, little is known about the underlying biological mechanisms that lead to the differences in human. To improve our understanding of cognitive processes and identify potential biomarkers, we conducted a comprehensive investigation of 158 IQ-related genes selected from the literature. A genomic distribution analysis demonstrated that IQ-related genes were enriched in seven regions of chromosome 7 and the X chromosome. In addition, these genes were enriched in target lists of seven transcription factors and sixteen microRNAs. Using a network-based approach, we further reconstructed an IQ-related pathway from known human pathway interaction data. Based on this reconstructed pathway, we incorporated enriched drugs and described the importance of dopamine and norepinephrine systems in IQ-related biological process. These findings not only reveal several testable genes and processes related to IQ scores, but also have potential therapeutic implications for IQ-related mental disorders.
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页数：7
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