Autoinflammatory syndromes for the dermatologist

被引:17
作者
Davila-Seijo, Paula [1 ]
Hernandez-Martin, Angela [1 ]
Torrelo, Antonio [1 ]
机构
[1] Hosp Nino Jesus, Dept Dermatol, Madrid 28009, Spain
关键词
FAMILIAL MEDITERRANEAN FEVER; RECURRENT MULTIFOCAL OSTEOMYELITIS; PEDIATRIC GRANULOMATOUS ARTHRITIS; CONGENITAL DYSERYTHROPOIETIC ANEMIA; PERIODIC FEVER; HYPERIMMUNOGLOBULINEMIA-D; HYPER-IGD; PYODERMA-GANGRENOSUM; APHTHOUS STOMATITIS; CUTANEOUS MANIFESTATIONS;
D O I
10.1016/j.clindermatol.2014.02.004
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
While autoimmunity as cause of disease is well-established, other categories of immune-mediated diseases that are not produced by targeting of self-antigens by antibodies is in the process of being described. These so-called autoinflammatory diseases arise when an inappropriate activation of antigen-independent mechanisms occurs. Autoinflammatory diseases course with recurrent attacks of fever and multisystemic inflammation; however, the skin may also be affected by a variety of inflammatory manifestations that often alert the clinician about the presence of an autoinflammatory disease. Recognizing the cutaneous features of these syndromes will aid for prompt diagnosis and early treatment that is key for the quality of life and survival of the affected patients. In this paper, we focus on the skin manifestations of autoinflammatory diseases in children, which is the usual period of appearing of the first symptoms and signs. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:488 / 501
页数:14
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