Notch1;
hepatitis B virus X protein;
hepatocarcinogenesis;
Wnt/beta-catenin pathway;
HUMAN HEPATOCELLULAR-CARCINOMA;
SIGNALING PATHWAY;
BETA-CATENIN;
COLORECTAL-CANCER;
CELLS;
ACTIVATION;
RECEPTOR;
GROWTH;
FZD10;
EXPRESSION;
D O I:
10.3892/ijo.2014.2537
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Hepatitis B virus X protein (HBx) is implicated in the pathogenesis of hepatocellular carcinoma (HCC) via a network of signaling pathways. Notch pathway is a major member of the network. Notch signaling may generate opposing effect in different steps of carcinogenesis, depending on the tumor cell type and the status of other signaling pathways, such as Wnt signaling pathway. Our previous studies have shown that activated Notch1 signaling is required for HBx to promote proliferation and survival of human hepatic cell line L02. However, the exact mechanisms remain vague. Here, we used L02/HBx cell lines as a cell model to study the relationship between Notch and Wnt/beta-catenin pathways in promoting proliferation. We observed that activated Notch1 and Wnt/beta-catenin signaling pathways and L02 cell malignant transformation were induced by HBx. Inhibition of the Notch1 pathway decreased the activation of Wnt/beta-catenin pathway and cell proliferation, while inhibition of the Wnt/beta-catenin pathway impaired cell proliferation, but did not significantly affect Notch1 signaling pathway in L02/HBx cells. Furthermore, inhibition of the Wnt/beta-catenin pathway overcame the inhibition effect of knockdown Notch1 on proliferation and survival in L02/HBx cells. Additionally, the activity of Wnt/beta-catenin signaling appears to be consistent with Fzd10 expression. Therefore, we demonstrate that Wnt signaling is downstream of the Notch pathway in regulating proliferation of L02/HBx cells, and which may be related to Fzd10 instead of Fzd7. These data suggest a new model of HBx-related HCC via cooperation between Wnt and Notch pathways.
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Bengochea, A.
de Souza, M. M.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
de Souza, M. M.
Lefrancois, L.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Lefrancois, L.
Le Roux, E.
论文数: 0引用数: 0
h-index: 0
机构:
IARC, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Le Roux, E.
Galy, O.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Galy, O.
Chemin, I.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Chemin, I.
Kim, M.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Med Sch, Dept Med, Liver Res Ctr, Providence, RI USAINSERM, U871, F-69424 Lyon 03, France
Kim, M.
Wands, J. R.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Med Sch, Dept Med, Liver Res Ctr, Providence, RI USAINSERM, U871, F-69424 Lyon 03, France
Wands, J. R.
Trepo, C.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, France
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Trepo, C.
Hainaut, P.
论文数: 0引用数: 0
h-index: 0
机构:
IARC, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Hainaut, P.
Scoazec, J-Y
论文数: 0引用数: 0
h-index: 0
机构:
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, France
Hop Edouard Herriot, Anatomopathol Lab, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Scoazec, J-Y
Vitvitski, L.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Vitvitski, L.
Merle, P.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, France
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Fukukawa, Chikako
Hanaoka, Hirofumi
论文数: 0引用数: 0
h-index: 0
机构:
Gunma Univ, Grad Sch Med, Dept Bioimaging Informat Anal, Gunma 3718511, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Hanaoka, Hirofumi
Nagayama, Satoshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Nagayama, Satoshi
Tsunoda, Tatsuhiko
论文数: 0引用数: 0
h-index: 0
机构:
RIKEN, SNP Res Ctr, Lab Med Informat, Yokohama, Kanagawa 2300045, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Tsunoda, Tatsuhiko
Toguchida, Junya
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Frontier Med Sci, Kyoto 6068507, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Toguchida, Junya
Endo, Keigo
论文数: 0引用数: 0
h-index: 0
机构:
Gunma Univ, Grad Sch Med, Dept Nucl Med & Diagnost Radiol, Gunma 3718511, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Endo, Keigo
Nakamura, Yusuke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Nakamura, Yusuke
Katagiri, Toyomasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Hsieh, Antony
Kim, Hyeon-Seop
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Kim, Hyeon-Seop
Lim, Seung-Oe
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Lim, Seung-Oe
Yu, Dae-Yeul
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Anim Mol Physiol Res Unit, Taejon, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Yu, Dae-Yeul
Jung, Guhung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Bengochea, A.
de Souza, M. M.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
de Souza, M. M.
Lefrancois, L.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Lefrancois, L.
Le Roux, E.
论文数: 0引用数: 0
h-index: 0
机构:
IARC, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Le Roux, E.
Galy, O.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Galy, O.
Chemin, I.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Chemin, I.
Kim, M.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Med Sch, Dept Med, Liver Res Ctr, Providence, RI USAINSERM, U871, F-69424 Lyon 03, France
Kim, M.
Wands, J. R.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Med Sch, Dept Med, Liver Res Ctr, Providence, RI USAINSERM, U871, F-69424 Lyon 03, France
Wands, J. R.
Trepo, C.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, France
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Trepo, C.
Hainaut, P.
论文数: 0引用数: 0
h-index: 0
机构:
IARC, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Hainaut, P.
Scoazec, J-Y
论文数: 0引用数: 0
h-index: 0
机构:
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, France
Hop Edouard Herriot, Anatomopathol Lab, Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Scoazec, J-Y
Vitvitski, L.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
Vitvitski, L.
Merle, P.
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U871, F-69424 Lyon 03, France
Univ Lyon 1, Fac Med Laennec, IFR62, F-69008 Lyon, France
Hop Hotel Dieu, Hosp Civils Lyon, Hepatol Unit, F-69002 Lyon, FranceINSERM, U871, F-69424 Lyon 03, France
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Fukukawa, Chikako
Hanaoka, Hirofumi
论文数: 0引用数: 0
h-index: 0
机构:
Gunma Univ, Grad Sch Med, Dept Bioimaging Informat Anal, Gunma 3718511, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Hanaoka, Hirofumi
Nagayama, Satoshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Nagayama, Satoshi
Tsunoda, Tatsuhiko
论文数: 0引用数: 0
h-index: 0
机构:
RIKEN, SNP Res Ctr, Lab Med Informat, Yokohama, Kanagawa 2300045, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Tsunoda, Tatsuhiko
Toguchida, Junya
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Frontier Med Sci, Kyoto 6068507, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Toguchida, Junya
Endo, Keigo
论文数: 0引用数: 0
h-index: 0
机构:
Gunma Univ, Grad Sch Med, Dept Nucl Med & Diagnost Radiol, Gunma 3718511, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Endo, Keigo
Nakamura, Yusuke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
Nakamura, Yusuke
Katagiri, Toyomasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, JapanUniv Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo 1088639, Japan
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Hsieh, Antony
Kim, Hyeon-Seop
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Kim, Hyeon-Seop
Lim, Seung-Oe
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Lim, Seung-Oe
Yu, Dae-Yeul
论文数: 0引用数: 0
h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Anim Mol Physiol Res Unit, Taejon, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea
Yu, Dae-Yeul
Jung, Guhung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South KoreaSeoul Natl Univ, Dept Biol Sci, Coll Nat Sci, Seoul 151742, South Korea