Shared and Distinct Functions of Type I and Type III Interferons

被引：826

作者：

Lazear, Helen M. ^{[1
]}

Schoggins, John W. ^{[2
]}

Diamond, Michael S. ^{[3
,4
,5
,6
]}

机构：

[1] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[3] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[5] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[6] Washington Univ, Sch Med, Andrew M & Jane M Bursky Ctr Human Immunol & Immu, St Louis, MO 63110 USA

来源：

IMMUNITY | 2019年 / 50卷 / 04期

关键词：

CHRONIC HEPATITIS-C; REGULATORY FACTOR FAMILY; T-CELL RESPONSES; IFN-LAMBDA; ZIKA VIRUS; ADJUVANT THERAPY; PEGINTERFERON ALPHA-2A; STIMULATED GENES; PEGYLATED INTERFERON-ALPHA-2B; ANTIVIRAL PROTECTION;

D O I：

10.1016/j.immuni.2019.03.025

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I interferons (IFNs) (IFN-alpha,IFN-beta) and type III IFNs (IFN-lambda) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences. Here, we provide a comprehensive review of type I and type III IFN activities, highlighting shared and distinct features from molecular mechanisms through physiological responses. Beyond discussing canonical antiviral functions, we consider the adaptive immune primin anti-tumor, and autoimmune functions of IFNs. We discuss a model wherein type III IFNs serve as a front-line defense that controls infection at epithelial barriers while minimizing damaging inflammatory responses, reserving the more potent type I IFN response for when local responses are insufficient. In this context, we discuss current therapeutic applications targeting these cytokine pathways and hignlignt gaps in understanding of the biology of type I and type III IFNs in health and disease.

引用

页码：907 / 923

页数：17

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