Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils

被引：5

作者：

Cockeran, R

Theron, AJ

Feldman, C

Mitchell, TJ

Anderson, R

机构：

[1] Univ Pretoria, Fac Hlth Sci, Dept Immunol, Med Res Council Inflmmat & Immun, ZA-0001 Pretoria, South Africa

[2] Natl Lab Hlth Serv, Tshwane Acad Div, Pretoria, South Africa

[3] Univ Witwatersrand, Fac Hlth Sci, Dept Med, Div Pulm, Johannesburg, South Africa

[4] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow, Lanark, Scotland

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 07期

关键词：

D O I：

10.1128/IAI.72.7.4327-4329.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pneumolysin (4.18 ng/ml)-mediated influx of Ca2+ and augmentation of the chemoattractant-activated generation of reactive oxidants was antagonized by pretreatment of human neutrophils with the omega-3 polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid (1.25 to 5 mug/ml). These agents may have potential in attenuating the proinflammatory properties of this pneumococcal toxin.

引用

页码：4327 / 4329

页数：3

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