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Synthesis, structural characterization, biological evaluation and molecular docking studies of new platinum(II) complexes containing isocyanides
被引:11
作者:
Fereidoonnezhad, Masood
[1
]
Shahsavari, Hamid R.
[2
]
Abedanzadeh, Sedigheh
[3
]
Nezafati, Ali
[1
,4
]
Khazali, Ali
[1
,4
]
Mastrorilli, Piero
[5
]
Babaghasabha, Mojgan
[2
]
Webb, James
[9
]
Faghih, Zeinab
[6
]
Faghih, Zahra
[7
]
Bahemmat, Samira
[8
]
Beyzavi, M. Hassan
[9
]
机构:
[1] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Toxicol Res Ctr, Dept Med Chem,Sch Pharm, Ahvaz, Iran
[2] IASBS, Dept Chem, Zanjan 4513766731, Iran
[3] Isfahan Univ Technol, Dept Chem, Esfahan 84156, Iran
[4] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran
[5] Politecn Bari, DICATECh, I-70125 Bari, Italy
[6] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
[7] Shiraz Univ Med Sci, Shiraz Inst Canc Res, Sch Med, Shiraz, Iran
[8] Chem & Chem Engn Res Ctr Iran, Tehran 1496813151, Iran
[9] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA
关键词:
CRYSTAL-STRUCTURE;
METAL-COMPLEXES;
ORGANOPLATINUM(II) COMPLEXES;
ORGANOMETALLIC PALLADIUM;
CYTOTOXIC ACTIVITY;
ELECTRONIC NOSE;
IN-VITRO;
ANTITUMOR;
DERIVATIVES;
LIGANDS;
D O I:
10.1039/c7nj04819j
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Herein, new Pt(ii) complexes [R2Pt(CNR)(2)] (1a-c; R = Me and 2a-c; R = p-tolyl) were synthesized by the reaction of the precursor complexes cis,cis-[Me2Pt(-SMe2)(2)PtMe2], A, and cis-[(p-tolyl)(2)Pt(SMe2)(2)], B, with four and two equivalents of different types of isocyanide ligands (CNR; R = a; t-butyl, b; benzyl, and c; cyclohexyl isocyanide), respectively. All complexes were characterized by FTIR and NMR spectroscopies, and the structure of 2b was confirmed by single-crystal X-ray determination. The evaluation of the cytotoxicity of 1a-c and 2a-c against three human cancer cell lines, namely A549 (non-small cell lung cancer cell line), SKOV3 (human ovarian cancer cell line), and MCF-7 (human breast cancer cell line), revealed promising antitumor activities for 1b and 2a in comparison with that of the standard cisplatin. Moreover, 1b effectively rendered apoptosis-inducing activities to the MCF-7 cancer cell line. The electrophoresis mobility shift assays on plasmids as well as molecular docking studies on DNA structures effectively revealed the specific binding site, binding mode, and the best orientation of the complexes to DNA.
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页码:8681 / 8692
页数:12
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