Cu(I)-Catalyzed Synthesis of 2-Substituted Benzimidazoles from 2-Iodoanilines and Amides

被引：14

作者：

Yuan, Hua ^{[1
,2
]}

Chen, Yongxin ^{[1
,2
]}

Song, Jinli ^{[1
,2
]}

Chen, Chunxia ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 10期

基金：

中国国家自然科学基金;

关键词：

2-substituted benzimidazoles; CuI; DMEDA; 2-iodoanilines; amides; synthesis; CATALYZED REGIOSPECIFIC SYNTHESIS; N BOND FORMATION; ONE-STEP; ARYL; AMINATION; BENZOTHIAZOLES; BENZAZOLES; MICROWAVE; ALDEHYDES; AGENTS;

D O I：

10.1002/cjoc.201300429

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient approach to the synthesis of 2-substituted benzimidazoles has been developed via CuI/DMEDA-catalyzed coupling reaction and post-cyclization with glacial acetic acid from readily available 2-iodoanilines and amides. This method is suitable for the construction of a variety of benzimidazoles in moderate to good yields under short reaction times.

引用

页码：1247 / 1249

页数：3

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