VIRULIGN: fast codon-correct alignment and annotation of viral genomes

被引：43

作者：

Libin, Pieter J. K. ^{[1
,2
]}

Deforche, Koen ^{[3
]}

Abecasis, Ana B. ^{[4
]}

Theys, Kristof ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med, Lab Clin & Evolutionary Virol, B-3000 Leuven, Belgium

[2] Vrije Univ Brussel, Artificial Intelligence Lab, Dept Comp Sci, B-1050 Brussels, Belgium

[3] Emweb, B-3020 Herent, Belgium

[4] Inst Hyg & Trop Med, Ctr Global Hlth & Trop Med, P-1349008 Lisbon, Portugal

来源：

BIOINFORMATICS | 2019年 / 35卷 / 10期

基金：

比利时弗兰德研究基金会;

关键词：

MULTIPLE SEQUENCE ALIGNMENT; DYNAMICS;

D O I：

10.1093/bioinformatics/bty851

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Virus sequence data are an essential resource for reconstructing spatiotemporal dynamics of viral spread as well as to inform treatment and prevention strategies. However, the potential benefit of these applications critically depends on accurate and correctly annotated alignments of genetically heterogeneous data. VIRULIGN was built for fast codon-correct alignments of large datasets, with standardized and formalized genome annotation and various alignment export formats. Availability and implementation VIRULIGN is freely available at https://github.com/rega-cev/virulign as an open source software project. Supplementary information Supplementary data is available at Bioinformatics online.

引用

页码：1763 / 1765

页数：3

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