Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour

被引：121
作者：
Clarke, G. [1 ,2 ]
O'Mahony, S. M. [1 ,3 ]
Dinan, T. G. [1 ,2 ]
Cryan, J. F. [1 ,3 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland
[3] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
来源：
ACTA PAEDIATRICA | 2014年 / 103卷 / 08期
基金：
爱尔兰科学基金会;
关键词：
Behaviour; Brain Development; Breastfeeding; Early Life; Microbiota; INTESTINAL MICROBIOTA; HUMAN-MILK; MATERNAL SEPARATION; STRESS-RESPONSE; IMMUNE-SYSTEM; PRETERM; IMPACT; MECHANISMS; CORTISOL; INFANTS;
D O I：
10.1111/apa.12674
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The infant gut microbiome is dynamic, and radical shifts in composition occur during the first 3 years of life. Disruption of these developmental patterns, and the impact of the microbial composition of our gut on brain and behaviour, has attracted much recent attention. Integrating these observations is an important new research frontier. Conclusion: Early-life perturbations of the developing gut microbiota can impact on the central nervous system and potentially lead to adverse mental health outcomes.
引用
收藏
页码：812 / 819
页数：8
相关论文
共 61 条
  • [21] Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns
    Dominguez-Bello, Maria G.
    Costello, Elizabeth K.
    Contreras, Monica
    Magris, Magda
    Hidalgo, Glida
    Fierer, Noah
    Knight, Rob
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (26) : 11971 - 11975
  • [22] Effect of Intestinal Microbial Ecology on the Developing Brain
    Douglas-Escobar, Martha
    Elliott, Elizabeth
    Neu, Josef
    [J]. JAMA PEDIATRICS, 2013, 167 (04) : 374 - 379
  • [23] Mom Knows Best: The Universality of Maternal Microbial Transmission
    Funkhouser, Lisa J.
    Bordenstein, Seth R.
    [J]. PLOS BIOLOGY, 2013, 11 (08)
  • [24] Bacterial infection causes stress-induced memory dysfunction in mice
    Gareau, Melanie G.
    Wine, Eytan
    Rodrigues, David M.
    Cho, Joon Ho
    Whary, Mark T.
    Philpott, Dana J.
    MacQueen, Glenda
    Sherman, Philip M.
    [J]. GUT, 2011, 60 (03) : 307 - 317
  • [25] Perinatal factors and the development of autism - A population study
    Glasson, EJ
    Bower, C
    Petterson, B
    de Klerk, N
    Chaney, G
    Hallmayer, JF
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2004, 61 (06) : 618 - 627
  • [26] Grey KR, HUMAN MILK CORTISOL
  • [27] Is It Time for a Metagenomic Basis of Therapeutics?
    Haiser, Henry J.
    Turnbaugh, Peter J.
    [J]. SCIENCE, 2012, 336 (6086) : 1253 - 1255
  • [28] Species comparison of anatomical and functional immune system development
    Holsapple, MP
    West, LJ
    Landreth, KS
    [J]. BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 2003, 68 (04) : 321 - 334
  • [29] Relationships between adrenocorticotropic hormone and cortisol are altered during clustered nursing care in preterm infants born at extremely low gestational age
    Holsti, Liisa
    Weinberg, Joanne
    Whitfield, Michael F.
    Grunau, Ruth E.
    [J]. EARLY HUMAN DEVELOPMENT, 2007, 83 (05) : 341 - 348
  • [30] Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
    Hsiao, Elaine Y.
    McBride, Sara W.
    Hsien, Sophia
    Sharon, Gil
    Hyde, Embriette R.
    McCue, Tyler
    Codelli, Julian A.
    Chow, Janet
    Reisman, Sarah E.
    Petrosino, Joseph F.
    Patterson, Paul H.
    Mazmanian, Sarkis K.
    [J]. CELL, 2013, 155 (07) : 1451 - 1463
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