Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour

被引：123
作者：
Clarke, G. [1 ,2 ]
O'Mahony, S. M. [1 ,3 ]
Dinan, T. G. [1 ,2 ]
Cryan, J. F. [1 ,3 ]
机构：
[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland
[3] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
来源：
ACTA PAEDIATRICA | 2014年 / 103卷 / 08期
基金：
爱尔兰科学基金会;
关键词：
Behaviour; Brain Development; Breastfeeding; Early Life; Microbiota; INTESTINAL MICROBIOTA; HUMAN-MILK; MATERNAL SEPARATION; STRESS-RESPONSE; IMMUNE-SYSTEM; PRETERM; IMPACT; MECHANISMS; CORTISOL; INFANTS;
D O I：
10.1111/apa.12674
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The infant gut microbiome is dynamic, and radical shifts in composition occur during the first 3 years of life. Disruption of these developmental patterns, and the impact of the microbial composition of our gut on brain and behaviour, has attracted much recent attention. Integrating these observations is an important new research frontier. Conclusion: Early-life perturbations of the developing gut microbiota can impact on the central nervous system and potentially lead to adverse mental health outcomes.
引用
收藏
页码：812 / 819
页数：8
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