α-lipoic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity

被引：80

作者：

Aguirre, N ^{[1
]}

Barrionuevo, M ^{[1
]}

Ramírez, MJ ^{[1
]}

Del Río, J ^{[1
]}

Lasheras, B ^{[1
]}

机构：

[1] Univ Navarra, Sch Med, Dept Pharmacol, Pamplona 31008, Spain

来源：

NEUROREPORT | 1999年 / 10卷 / 17期

关键词：

5-HT (serotonin; 5-hydroxytryptamine); glial fibrillary acidic protein (GFAP); alpha-lipoic acid (thioctic acid); 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy);

D O I：

10.1097/00001756-199911260-00039

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single administration of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine (5-HT) content and [H-3]paroxetine-labeled 5-HT transporter density in the frontal cortex, striatum and hippocampus by 40-60% 1 week later, MDMA treatment also increased glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus. Repeated administration of the metabolic antioxidant alpha-lipoic acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did not prevent the acute hyperthermia induced by the drug; however, it fully prevented the serotonergic deficits and the changes in the glial response induced by MDMA. These results further support the hypothesis that free radical formation is responsible for MDMA-induced neurotoxicity. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：3675 / 3680

页数：6

共 24 条

[11]

LIPTON SA, 1994, NEW ENGL J MED, V330, P613

[12]

Malberg JE, 1996, J PHARMACOL EXP THER, V278, P258

[13]

Malberg JE, 1998, J NEUROSCI, V18, P5086

[14] CHARACTERIZATION OF [H-3] PAROXETINE BINDING IN RAT-BRAIN [J].

MARCUSSON, JO ;

BERGSTROM, M ;

ERIKSSON, K ;

ROSS, SB .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1783-1790

[15] QUANTITATIVE ASPECTS OF REACTIVE GLIOSIS - A REVIEW [J].

NORTON, WT ;

AQUINO, DA ;

HOZUMI, I ;

CHIU, FC ;

BROSNAN, CF .

NEUROCHEMICAL RESEARCH, 1992, 17 (09) :877-885

[16] The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy') [J].

O'Shea, E ;

Granados, R ;

Esteban, B ;

Colado, MI ;

Green, AR .

NEUROPHARMACOLOGY, 1998, 37 (07) :919-926

[17] QUANTITATIVE FEATURES OF REACTIVE GLIOSIS FOLLOWING TOXICANT-INDUCED DAMAGE OF THE CNS [J].

OCALLAGHAN, JP .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1993, 679 :195-210

[18] Neuroprotection by the metabolic antioxidant alpha-lipoic acid [J].

Packer, L ;

Tritschler, HJ ;

Wessel, K .

FREE RADICAL BIOLOGY AND MEDICINE, 1997, 22 (1-2) :359-378

[19] EXTENSIVE LOSS OF BRAIN DOPAMINE AND SEROTONIN INDUCED BY CHRONIC ADMINISTRATION OF MPTP IN THE MARMOSET [J].

PEREZOTANO, I ;

HERRERO, MT ;

OSET, C ;

DECEBALLOS, ML ;

LUQUIN, MR ;

OBESO, JA ;

DELRIO, J .

BRAIN RESEARCH, 1991, 567 (01) :127-132

[20] ACTIVATION OF GLYCOGEN-PHOSPHORYLASE BY SEROTONIN AND 3,4-METHYLENEDIOXYMETHAMPHETAMINE IN ASTROGLIAL-RICH PRIMARY CULTURES - INVOLVEMENT OF THE 5-HT2A RECEPTOR [J].

POBLETE, JC ;

AZMITIA, EC .

BRAIN RESEARCH, 1995, 680 (1-2) :9-15

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