Use of a GABA-transaminase agonist for treatment of infantile autism

被引：11

作者：

Cohen, BI ^{[1
]}

机构：

[1] ED Labs, Hackensack, NJ 07606 USA

来源：

MEDICAL HYPOTHESES | 2002年 / 59卷 / 01期

关键词：

D O I：

10.1016/S0306-9877(02)00157-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This paper describes the use of a GABA-transaminase agonist for the treatment of infantile autism. An approximate one third reduction of GABA and ammonia levels for an autistic patient with noticeable improvement of verbal/language skills and a reduction of repetitious ritualistic self-stimulatory behavior (stimming) was observed. A reduction of the plasma GABA (by administrating a GABA-T agonist, Imipramine) probably results in more axon(s)-to-oligodendrocyte signaling in the corpus callosum and it is postulated that this could result in a reduction of the autistic features for the patient. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：115 / 116

页数：2