Cancer's Fuel Choice: New Flavors for a Picky Eater

被引：125

作者：

DeNicola, Gina M. ^{[1
]}

Cantley, Lewis C. ^{[1
]}

机构：

[1] Weill Cornell Med Coll, Meyer Canc Ctr, New York, NY 10065 USA

来源：

MOLECULAR CELL | 2015年 / 60卷 / 04期

关键词：

MITOCHONDRIAL PYRUVATE CARRIER; ALPHA-KETOGLUTARATE; CELL-SURVIVAL; REDUCTIVE CARBOXYLATION; TUMOR-CELLS; GLUTAMINE; GLUCOSE; GROWTH; METABOLISM; MAINTAINS;

D O I：

10.1016/j.molcel.2015.10.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Otto Warburg discovered that cancer cells exhibit a high rate of glycolysis in the presence of ample oxygen, a process termed aerobic glycolysis, in 1924 (Warburg et al., 1924). Since then we have significantly advanced our understanding of cancers' fuel choice to meet their demands for energy and for the production of biosynthetic precursors. In this review, we will discuss the preferred nutrients of cancer cells and how they are utilized to satisfy their bioenergetic and biosynthetic needs. In addition, we will describe how cell intrinsic and extrinsic factors such as oncogene mutations, nutrient and oxygen availability, and other microenvironmental factors influence fuel choice.

引用

页码：514 / 523

页数：10

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