Cancer cachexia: Diagnosis, assessment, and treatment

被引：145

作者：

Sadeghi, Mohammadamin ^{[1
,2
,3
]}

Keshavarz-Fathi, Mahsa ^{[2
,3
]}

Baracos, Vickie ^{[4
]}

Arends, Jann ^{[5
]}

Mahmoudi, Maryam ^{[2
,6
,7
]}

Rezaei, Nima ^{[8
,9
,10
]}

机构：

[1] USERN, MMIG, Tehran, Iran

[2] USERN, CIP, Tehran, Iran

[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran

[4] Univ Alberta, Dept Oncol, Div Palliat Care Med, Edmonton, AB, Canada

[5] Univ Freiburg, Fac Med, Dept Med 1, Med Ctr, Freiburg, Germany

[6] USERN, Dietitians & Nutr Experts Team DiNET, Tehran, Iran

[7] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran

[8] Univ Tehran Med Sci, Childrens Med Ctr, Res Ctr Immunodeficiencies, Tehran, Iran

[9] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[10] USERN, CIP, Sheffield, S Yorkshire, England

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 127卷

关键词：

Cancer cachexia; Nutrition; Palliative medicine; Biomarker; Pharmacologic treatment; Nutritional treatment; Exercise; Psychological treatment; QUALITY-OF-LIFE; CELL LUNG-CANCER; PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; MINI NUTRITIONAL ASSESSMENT; LEAN BODY-MASS; DIFFERENT ASSESSMENT CRITERIA; SUBJECTIVE GLOBAL ASSESSMENT; HYPOTHALAMIC NEUROPEPTIDE-Y; SKELETAL-MUSCLE MASS;

D O I：

10.1016/j.critrevonc.2018.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer cachexia is a multi-factorial syndrome, which negatively affects quality of life, responsiveness to chemotherapy, and survival in advanced cancer patients. Our understanding of cachexia has grown greatly in recent years and the roles of many tumor-derived and host-derived compounds have been elucidated as mediators of cancer cachexia. However, cancer cachexia remains an unmet medical need and attempts towards a standard treatment guideline have been unsuccessful. This review covers the diagnosis, assessment, and treatment of cancer cachexia; the elements impeding the formulation of a standard management guideline; and future directions of research for the improvement and standardization of current treatment procedures.

引用

页码：91 / 104

页数：14

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