Agarose bioplastic-based drug delivery system for surgical and wound dressings

被引：60

作者：

Awadhiya, Ankur ^{[1
]}

Tyeb, Suhela ^{[1
]}

Rathore, Kalpana ^{[2
]}

Verma, Vivek ^{[2
,3
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Biol Sci & Bioengn, Kanpur, Uttar Pradesh, India

[2] Indian Inst Technol Kanpur, Dept Mat Sci & Engn, Kanpur, Uttar Pradesh, India

[3] Indian Inst Technol Kanpur, Ctr Environm Sci & Engn, Kanpur, Uttar Pradesh, India

来源：

ENGINEERING IN LIFE SCIENCES | 2017年 / 17卷 / 02期

关键词：

Agarose bioplastic; Biocompatibility; Drug delivery; Haemocompatibility; Swelling; VENOUS LEG ULCERS; IN-VITRO; HEALING PATHOPHYSIOLOGY; ANAEROBIC-BACTERIA; MAMMALIAN-CELLS; FOOT INFECTIONS; SKIN WOUNDS; BIOCOMPATIBILITY; MICROBIOLOGY; GROWTH;

D O I：

10.1002/elsc.201500116

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed anagarose-based biocompatible drug delivery vehicle. The vehicle is in the form of thin, transparent, strong and flexible films. The biocompatibility and haemocompatibility of the films is confirmed using direct and indirect contact biological assay. Contact angle measurement exhibits hydrophilic nature of the films, and protein adsorption test shows low protein adsorption on the film surface. Drugs, antibiotics and antiseptics, retain their potency after their incorporation into the films. Our bioplastic films can be a versatile medium for drug delivery applications, especially as wound and surgical dressings where a fast drug release rate is desired.

引用

页码：204 / 214

页数：11

共 47 条

[1]

[Anonymous], COCHRANE DATABASE SY

[2]

[Anonymous], COCHRANE DATABASE SY

[3]

Berezhna LG, 2013, PROG BIOMATER, V2, DOI 10.1186/2194-0517-2-4

[4] Wound healing dressings and drug delivery systems: A review [J].

Boateng, Joshua S. ;

Matthews, Kerr H. ;

Stevens, Howard N. E. ;

Eccleston, Gillian M. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2892-2923

[5]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[6] Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization [J].

Brill, A ;

Dashevsky, O ;

Rivo, J ;

Gozal, Y ;

Varon, D .

CARDIOVASCULAR RESEARCH, 2005, 67 (01) :30-38

[7]

CARLSSON J, 1978, IN VITRO CELL DEV B, V14, P860

[8] Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents [J].

Citron, Diane M. ;

Goldstein, Ellie J. C. ;

Merriam, C. Vreni ;

Lipsky, Benjamin A. ;

Abramson, Murray A. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (09) :2819-2828

[9] Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and nonhealing chronic venous leg ulcers [J].

Davies, CE ;

Hill, KE ;

Wilson, MJ ;

Stephens, P ;

Hill, CM ;

Harding, KG ;

Thomas, DW .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (08) :3549-3557

[10] A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs [J].

Davies, Charlotte E. ;

Hill, Katja E. ;

Newcombe, Robert G. ;

Stephens, Phil ;

Wilson, Melanie J. ;

Harding, Keith G. ;

Thomas, David W. .

WOUND REPAIR AND REGENERATION, 2007, 15 (01) :17-22

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