Agarose bioplastic-based drug delivery system for surgical and wound dressings

被引：60

作者：

Awadhiya, Ankur ^{[1
]}

Tyeb, Suhela ^{[1
]}

Rathore, Kalpana ^{[2
]}

Verma, Vivek ^{[2
,3
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Biol Sci & Bioengn, Kanpur, Uttar Pradesh, India

[2] Indian Inst Technol Kanpur, Dept Mat Sci & Engn, Kanpur, Uttar Pradesh, India

[3] Indian Inst Technol Kanpur, Ctr Environm Sci & Engn, Kanpur, Uttar Pradesh, India

来源：

ENGINEERING IN LIFE SCIENCES | 2017年 / 17卷 / 02期

关键词：

Agarose bioplastic; Biocompatibility; Drug delivery; Haemocompatibility; Swelling; VENOUS LEG ULCERS; IN-VITRO; HEALING PATHOPHYSIOLOGY; ANAEROBIC-BACTERIA; MAMMALIAN-CELLS; FOOT INFECTIONS; SKIN WOUNDS; BIOCOMPATIBILITY; MICROBIOLOGY; GROWTH;

D O I：

10.1002/elsc.201500116

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have developed anagarose-based biocompatible drug delivery vehicle. The vehicle is in the form of thin, transparent, strong and flexible films. The biocompatibility and haemocompatibility of the films is confirmed using direct and indirect contact biological assay. Contact angle measurement exhibits hydrophilic nature of the films, and protein adsorption test shows low protein adsorption on the film surface. Drugs, antibiotics and antiseptics, retain their potency after their incorporation into the films. Our bioplastic films can be a versatile medium for drug delivery applications, especially as wound and surgical dressings where a fast drug release rate is desired.

引用

页码：204 / 214

页数：11

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