Lung function in children with sickle cell disease from Central Africa

被引：10

作者：

Arigliani, Michele ^{[1
]}

Kitenge, Robert ^{[2
,3
]}

Castriotta, Luigi ^{[4
]}

Ndjule, Pathy ^{[5
]}

Barbato, Vincenzo ^{[6
]}

Cogo, Paola ^{[1
]}

Tshilolo, Leon ^{[2
,3
]}

机构：

[1] Univ Hosp Udine, Dept Med, Udine, Italy

[2] Ctr Hosp Monkole, Serv Pediat, Kinshasa, DEM REP CONGO

[3] Ctr Format & Appui Sanitaire CEFA, Kinshasa, DEM REP CONGO

[4] Univ Hosp Udine, Inst Hyg & Clin Epidemiol, Udine, Italy

[5] Mediprox Clin, Kinshasa, DEM REP CONGO

[6] Univ Udine, Sch Med, Udine, Italy

来源：

THORAX | 2019年 / 74卷 / 06期

关键词：

ABNORMAL PULMONARY-FUNCTION; SPIROMETRY;

D O I：

10.1136/thoraxjnl-2018-212720

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Lung function in patients with sickle cell anaemia (SCA) living in sub-Saharan Africa is largely unknown. Anthropometry and spirometry were cross-sectionally evaluated in patients with SCA (HbSS) aged 6-18 years and in schoolchildren from the Democratic Republic of the Congo. The Global Lung Initiative 2012 spirometry reference values were used. A total of 112 patients and 377 controls were included. Twenty-six per cent of patients with SCA had spirometry findings suggestive of a restrictive pattern and 41% had a FEV1 z-score <5th percentile. Wasting, increasing age and female sex were independently associated with increased risk of restrictive spirometry pattern in patients with SCA. Longitudinal studies could clarify the prognostic meaning of these findings.

引用

收藏

页码：604 / 606

页数：3

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